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| 抑瘤素M在肝细胞癌发生发展中的作用机制与临床意义研究进展 |
| 庞丽丽1,2, 陈王成2,3, 兰月梅1,2, 张百红1 |
1.甘肃中医药大学第一临床医学院, 甘肃 兰州 730050 2.联勤保障部队第九四〇医院肿瘤科, 甘肃 兰州 730050 3.西北民族大学医学部, 甘肃 兰州 730050 |
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[1] Di Maira G,Foglia B,Napione L,et al.Oncostatin M is overexpressed in NASH-related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis[J].Pathol,2022,257(1): 82-95. [2] Ganesan P,Kulik LM.Hepatocellular Carcinoma: New Developments[J].Clin Liver Dis,2023,27(1):85-102. [3] Bray F,Laversanne M,Sung H,et al.Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J].CA Cancer Clin,2024,74(3):229-263. [4] Fu C,Wang L,Tian G,et al.Enhanced anticancer effect of oncostatin M combined with salinomycin in CD133(+) HepG2 liver cancer cells[J].Oncol Lett,2019,17(2):1798-1806. [5] Di Maira G,Foglia B,Napione L,et al.Oncostatin M is overexpressed in NASH-related hepatocellular carcinoma and promotes cancer cell invasiveness and angiogenesis[J].Pathol,2022,257(1):82-95. [6] Alexander KA,Tseng HW,Fleming W,et al.Inhibition of JAK1/2 tyrosine kInases reduces neurogenic heterotopic ossification after spinal cord injury[J].Front Immunol,2019(10):377. [7] Takata F,Dohgu S,Sakaguchi S,et al.Oncostatin-M-reactive pericytes aggravate blood-brain barrier dysfunction by activating JAK/STAT3 signaling in vitro[J].Neuroscience,2019(422):12-20. [8] Guo YJ,Pan WW,Liu SB,et al.ERK/MAPK signalling pathway and tumorigenesis[J].Exp Ther Med,2020,19(3):1997-2007. [9] Matsushima H,Fujimoto M,Tsutsui H,Nakamura K,Kohno K,Yamada T,et al.Oncostatin M derived from activated macrophages and neutrophils drives the progression of hepatocellular carcinoma by inducing epithelial-mesenchymal transition and fibrosis[J].Pathol,2022,256(4):399-412. [10] Yang X,Shao C,Duan L,et al.Oncostatin M promotes hepatic progenitor cell activation and hepatocarcinogenesis via macrophage-derived tumor necrosis factor-α[J].Cancer Lett,2021(517):46-54. [11] Geethadevi A,Nair A,Parashar D,et al.Oncostatin M receptor-targeted antibodies suppress STAT3 signaling and inhibit ovarian cancer growth[J].Cancer Res,2021,81(20):5336-5352. [12] Polak KL,Tamagno I,Parameswaran N,et al.Oncostatin-M and OSM-receptor feed-forward activation of MAPK induces separable stem-like and mesenchymal programs[J].Mol Cancer Res,2023,21(9):975-990. [13] Wang XY,Liao Y,Wang RQ,et al.Tribbles pseudokinase 3 converts sorafenib therapy to neutrophil-mediated lung metastasis in hepatocellular carcinoma[J].Adv Sci (Weinh),2025,12(13):2413682. [14] Shigematsu Y,Tanaka K,Amori G,et al.Potential involvement of oncostatin M in the immunosuppressive tumor immune microenvironment in hepatocellular carcinoma with vessels encapsulating tumor clusters[J].Hepatol Res,2024,54(4):368-381. |
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