Abstract：Objective: To study the effects of liraglutide on the changes in oxidative stress levels in ob/ob mice and high-fat-fed ob/ob mice, and observe the changes in alveolar bone microstructure and the impact on bone metabolism. Methods:Wild type C57BL/6 mice were used as the control group (NC), and ob/ob mice were randomly divided into ob/ob group, ob/ob group+high-fat diet (HFD group), ob/ob+high-fat diet+liraglutide group (Lir group). After 8 weeks of feeding, body weight and body fat ratio were measured. HE staining was used to observe changes in liver cells and absorption of alveolar bone. The height of alveolar bone absorption at the cervical part of the tooth was measured under microscope. The expression of liver function,oxidative stress markers, and inflammatory factors was detected. Results: Compared with the NC group and ob/ob group, the HFD group showed more significant alveolar bone resorption in mice (P<0.05), while the Lir group showed some relief in alveolar bone resorption compared to the high-fat group (P<0.05). Compared with the NC group and ob/ob group, the HFD group showed an increase in inflammatory factors and an increase in oxidative stress markers in the periodontal tissue of mice (P<0.05), while the Lir group showed a significant decrease in inflammatory factors and a decrease in oxidative stress markers in the periodontal tissue of mice (P<0.05). Conclusion: Liraglutide can reduce lipid metabolism and liver lipid deposition in ob/ob mice fed with high-fat diet, decrease the accumulation of inflammatory factors, and improve alveolar bone resorption. Its mechanism may be related to the inhibition of periodontal oxidative stress.
白相宇, 郝妍, 郭晓宇, 张海龙, 王泽成. Liraglutide对高脂喂养肥胖小鼠肝脏影响及在牙槽骨吸收修复的作用[J]. 河北医学, 2025, 31(11): 1830-1834.
BAI Xiangyu, HAO Yan, GUO Xiaoyu, et al. Liraglutide Effects on Liver within High Fat Fed Obese Mice and the Effect in Repairing Alveolar Bone Defects. HeBei Med, 2025, 31(11): 1830-1834.
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2025, Vol. 31 
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