Abstract：Objective: To investigate the expression and predictive value of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), neutrophil apolipoprotein (HNL), lactate dehydrogenase (LDH) in serum of patients with acute ischemic stroke (AIS) and hospital infection. Methods: A total of 136 patients with AIS admitted to our hospital between January 2020 and August 2023 were selected and divided into 58 cases in the infected group and 78 cases in the non-infected group according to whether or not hospital infection occurred. Serum LDH levels were detected by colorimetric assay; the expression levels of sTREM-1 and HNL were detected by enzyme-linked immunosorbent assay (ELISA); Pearson correlation analysis was performed to analyze the correlation between serum sTREM-1, HNL, and LDH, and Hs-CRP, WBC, and D-D; Logistic analysis was used to analyze the influencing factors. ROC curve was used to analyze the predictive value. Results: The levels of serum Hs-CRP, WBC, DD, sTREM-1, HNL and LDH in infected group were significantly higher than those in non-infected group (P<0.05); the Pearson's correlation analysis showed that serum sTREM-1, HNL, LDH were positively correlated with Hs-CRP, WBC, and DD (P<0.05); Serum sTREM-1, HNL, LDH, Hs-CRP, WBC, and D-D were all influencing factors in AIS combined with hospital-acquired infections (P<0.05); and ROC curves showed that serum sTREM-1, HNL and LDH jointly predicted AIS combined hospital infection with an AUC of 0.919, which was significantly higher than that of the three tests alone (Z=3.447, 2.332, 2.442, all P<0.05). Conclusion: The expression levels of serum sTREM-1, HNL, and LDH are obviously increased in patients with AIS complicated by hospital infection, and the combination of the three is more effective in predicting AIS complicated by hospital infection.
王魁恩, 张永娜, 张青坤, 孙志. 急性缺血性脑卒中合并医院感染患者血清中sTREM-1 HNL LDH的表达水平及其对感染的预测价值[J]. 河北医学, 2026, 32(1): 74-79.
WANG Kuien, ZHANG Yongna, ZHANG Qingkun, et al. Expression Levels of sTREM-1 HNL and LDH in Serum of Hospital-Acquired Infection Patients and Their Predictive Value for Infection. HeBei Med, 2026, 32(1): 74-79.
[1] 徐焕昌,王雪梅.系统免疫炎症指数与急性缺血性脑卒中相关性研究进展[J].中国神经免疫学和神经病学杂志,2023,30(4):277-281. [2] Saini V,Guada L,Yavagal DR.Global epidemiology of stroke and access to acute ischemic stroke interventions[J].Neurology,2021,97(20):6-16. [3] Dholariya S,Parchwani D,Singh R,et al.Utility of P-SEP,sTREM-1 and suPAR as novel sepsis biomarkers in SARS-CoV-2 infection[J].Indian journal of clinical biochemistry,2022,37(2):131-138. [4] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666-682. [5] 中华人民共和国卫生部.医院感染诊断标准(试行)[J].中华医学杂志,2001,81(5):314-320. [6] Paul S,Candelario-Jalil E.Emerging neuroprotective strategies for the treatment of ischemic stroke:an overview of clinical and preclinical studies[J].Experimental Neurology,2021,335(2):113518-113526. [7] Da Silva-Neto PV,de Carvalho JCS,Pimentel VE,et al.sTREM-1 predicts disease severity and mortality in COVID-19 patients:involvement of peripheral blood leukocytes and MMP-8 activity[J].Viruses,2021,13(12):2521-2534. [8] Duman A,Akoz A,Kapci M,et al.Prognostic value of neglected biomarker in sepsis patients with the old and new criteria:predictive role of lactate dehydrogenase[J].American Journal of Emergency Medicine,2016,3(1):2167-2171. [9] Zheng Y,Hua L,Zhao Q,et al.The level of D-dimer is positively correlated with the severity of mycoplasma pneumoniae pneumonia in children[J].Frontiers in Cellular and Infection Microbiology,2021,11(1):687391.
2026, Vol. 32 
冀公网安备13080202000786号