外周血OPN miR-142-5p诊断早期肝癌效能分析
任长蓉, 刘辉, 张凯虔, 孙启天, 李剑
承德医学院附属医院/河北省泛血管重点实验室, 河北 承德 067000
Analysis of the Diagnostic Efficacy of Circulating OPN and miR-142-5p in Early Detection of Hepatocellular Carcinoma
REN Changrong, LIU Hui, ZHANG Kaiqian, et al
Chengde Medical University Affiliated Hospital / Hebei Key Laboratory of Panvascular Diseases, Hebei Chengde 067000, China
摘要 目的: 探讨骨桥蛋白(OPN)、miR-142-5p和AFP对原发性肝细胞癌(HCC)的诊断价值。方法: 以我院就诊40例早期HCC患者,30例肝硬化(LC)患者,25例慢性肝炎(CH)患者为研究对象,对外周血OPN、miR-142-5p及AFP含量进行测定,并建立各指标对早期HCC诊断的受试者工作曲线(ROC)。结果: OPN、miR-142-5p及AFP具有以慢性肝病(CH+LC)患者为良性对照组诊断早期HCC效能,当3者(OPN+miR-142-5p+AFP)联合时,ROC下面积为0.935,灵敏度和特异性分别为73.53%和96.4%；结论: OPN和miR-142-5p是早期HCC诊断潜在标志物,和AFP联合应用能够提高诊断灵敏度,是对AFP的有利补充。
关键词 ：
原发性肝细胞癌 ,
骨桥蛋白 ,
miR-142-5p ,
甲胎蛋白
Abstract ：Objective: To investigate the diagnostic value of osteopontin (OPN), miR-142-5p and AFP in primary hepatocellular carcinoma (HCC). Methods: A total of 40 patients with HCC, 30 patients with liver cirrhosis (LC), and 25 patients with chronic hepatitis (CH) in our hospital were selected as the research subjects. The levels of circulating OPN, miR-142-5p, and AFP were measured, and the receiver operating characteristic (ROC) curve of each index for the diagnosis of HCC was plotted. Results: OPN, miR-142-5p, and AFP demonstrated diagnostic efficacy for HCC when using patients with chronic liver diseases (CH + LC) as the benign control group. When they (OPN+miR-142-5p+AFP) were combined, the area under ROC was 0.935, and the sensitivity and specificity were 73.53% and 96.4%. Conclusion: OPN and miR-142-5p are potential biomarkers for the diagnosis of HCC. Their combination with AFP can improve the diagnostic sensitivity.
Key words ：
Primary hepatocellular carcinoma
Osteopontin
miR-142-5p
Alpha-fetoprotein
Diagnosis
基金资助: 河北省承德市科学技术项目,(编号:202205B071)
通讯作者:
李剑
引用本文:
任长蓉, 刘辉, 张凯虔, 孙启天, 李剑. 外周血OPN miR-142-5p诊断早期肝癌效能分析[J]. 河北医学, 2025, 31(4): 625-629.
链接本文:
http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2025.04.016 或 http://www.hbyxzzs.cn/CN/Y2025/V31/I4/625
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2025, Vol. 31 
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