Abstract：Objective: To investigate the difference of survival rate between video-assisted thoracoscopic wedge resection versus lobectomy in patients with Stage T1 lung cancer. Methods: A total of 253 patients with stage T1 lung cancer, admitted from March 2022 to March 2023, were selected. Among them, 76 patients underwent wedge resection, and 177 patients underwent lobectomy. Clinical data were collected and compared. The Kaplan-Meier curves and Log-rank test were used to compare the prognosis of patients with stage T1 lung cancer treated with different surgical methods. While the Cox proportional hazards regression model was used to analyze the factors affecting the prognosis of lung cancer patients. Results: The surgery duration and intraoperative blood loss were longer and greater respectively in the lobectomy group than in the wedge resection group (P<0.05). The 2-year survival rates for the wedge resection and lobectomy groups were 71.0% and 81.3%, respectively (χ2=3.169, P=0.075), with no statistically significant difference (P>0.05). The results of Cox multivariate regression analysis showed that age ≥70 years, N1, and N2 were risk factors for the prognosis of lung cancer patients (HR=2.479, 3.881, 6.135), while moderate to high differentiation was a protective factor for prognosis (HR=0.319)(all P<0.05). Conclusion: There is no significant difference in overall survival between thoracoscopic wedge resection and lobectomy. Age, tumor differentiation and N stage are independent prognostic factors for lung cancer patients.
何华梅, 王导, 单隆昱, 罗东. 胸腔镜下肺楔形切除术与肺叶切除术对T1期肺癌患者生存率的影响[J]. 河北医学, 2026, 32(2): 300-305.
HE Huamei, WANG Dao, SHAN Longyu, et al. Impact of Video-assisted Thoracoscopic Wedge Resection versus Lobectomy on the Survival Rate of Patients with Stage T1 Lung Cancer. HeBei Med, 2026, 32(2): 300-305.
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2026, Vol. 32 
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