Abstract：Objective: To explore the value of ABCD2 score combined with peripheral blood homocysteine (Hcy) and glutathione peroxidase (GSH-Px) levels on predicting the prognosis of patients with transient ischemic attack (TIA). Methods: A total of 126 patients with TIA from December 2022 to August 2024 were retrospectively analyzed and included in TIA group. According to whether acute cerebral infarction occurred within 7 days, the patients in TIA group were divided into ACI group (n=29) and non-ACI group (n=97). The baseline data, ABCD2 score and peripheral blood indexes (Hcy, GSH-Px) were compared between ACI group and non-ACI group. ABCD2 score and peripheral blood indexes (Hcy, GSH-Px) were compared between ACI group and non-ACI group. Pearson correlation analysis was used to explore the correlation between each index and clinical data. Binary logistic equation was adopted to analyze the related influencing factors of acute cerebral infarction in patients. ROC curve was drawn to analyze the diagnostic value of ABCD2 score combined with peripheral blood Hcy and GSH-Px levels on the prognosis in TIA group. Results: Hypertension, diabetes, attack duration, attack frequency, TC and TG in ACI group were significantly higher than those in non ACI group (P<0.05). The ABCD2 scores and peripheral blood Hcy levels in the ACI group were significantly higher than those in the non ACI group (P<0.05), while GSH Px was significantly lower than those in the non ACI group (P<0.05). ABCD2 score and Hcy were significantly positively correlated with attack duration, attack frequency, TC and TG (P<0.05), and GSH-Px was significantly negatively correlated with each index (P<0.05). The ABCD2 score and peripheral blood Hcy level in ACI group were significantly higher (P<0.05) while the GSH-Px was significantly lower compared to non-ACI group (P<0.05). ABCD2 score and levels of Hcy and GSH-Px in peripheral blood were correlated with acute cerebral infarction (P<0.05). The AUCs of ABCD2 score, peripheral blood Hcy and GSH-Px in predicting the poor prognosis of patients were 0.638, 0.677 and 0.701 respectively. The AUC of the combination of the three indexes for poor prognosis of patients was 0.770, and the combined diagnostic value was higher. Conclusion: ABCD2 score and levels of peripheral blood Hcy and GSH-Px are correlated with transient ischemic attack and poor prognosis, which are expected to be used as reference indexes.
王一旭, 张静. ABCD2评分联合外周血Hcy GSH-Px水平预测短暂性脑缺血发作患者预后的价值分析[J]. 河北医学, 2025, 31(5): 800-805.
WANG Yixu, ZHANG Jing. Value of ABCD2 Score Combined with Peripheral Blood Hcy and GSH-Px Levels on Predicting the Prognosis of Patients with Transient Ischemic Attack. HeBei Med, 2025, 31(5): 800-805.
[1] Amin HP,Madsen TE,Bravata DM,et al.Diagnosis,workup,risk reduction of transient ischemic attack in the emergency department setting:a scientific statement from the American heart association[J].Stroke,2023,54(3):109-121. [2] Yang C,Jin A,Lin J,et al.Validation of the canadian TIA score to predict subsequent stroke risk in Chinese TIA patients[J].Cerebrovasc Dis,2022,51(6):735-743. [3] 王晓宇,楼滟,温良,等.急性缺血性脑卒中患者血清lncRNA MEG3、Hcy、MCP-1水平与脑梗死体积和神经功能缺损程度的关系[J].中国卫生检验杂志,2023,33(9):1090-1094. [4] 张蕊,陈后勤,杨进平,等.多模式CT指导下动脉溶栓对急性致残性非大血管脑梗死患者氧化应激、炎症反应及神经功能的影响[J].临床误诊误治,2024,37(12):57-61,68. [5] 中华医学会神经病学分会,中华医学会神经病学分会脑血管病学组.中国缺血性卒中和短暂性脑缺血发作二级预防指南2022[J].中华神经科杂志,2022,55(10):1071-1110. [6] 王丽,唐旭,杨月君,等.ABCD2评分和血清血小板活化因子水平对短暂性脑缺血发作进展为脑梗死的预测价值[J].安徽医药,2022,26(3):536-540. [7] 吕凤华,白银,刘鑫,等.Hcy、Lp-PLA2水平与短暂性脑缺血发作治愈后早期复发的关系[J].解放军医药杂志,2022,34(5):108-111. [8] Nizar D,Amine MM,Aissi M,et al.External validations of the ABCD2 score in prediction of stroke risk after transient ischemic attack.A Tunisian hospital-based cohort study[J].Int Neurosci,2023,133(11):1218-1223. [9] Wahi S,Michaleff ZA,Lomax P,et al.Evaluating the use of the ABCD2 score as a clinical decision aid in the emergency department:Retrospective observational study[J].Emerg Med Australas,2023,35(6):934-940. [10] Weng JX,Gu HQ,Wang S,et al.External validation of ABCD series scores for predicting early stroke events following transient ischemic attack in a large nationwide registry[J].Eur Stroke,2022,7(4):439-446. [11] Li X,Guo D,Hu Y,et al.Potential biomarkers and therapeutic targets:inflammation and oxidative stress in left carotid artery stenosis with coronary artery disease[J].Curr Pharm Des,2023,29(12):966-979. [12] Cui L,Lu P,Li S,et al.Relationship among homocysteine,inflammation and cognitive impairment in patients with acute ischemic stroke and transient ischemic attack[J].Neuropsychiatr Dis Treat,2021,17(1):3607-3616. [13] Zhao J,Zhu R,He F,et al.Neuroprotective effects of galectin1 on cerebral ischemia/reperfusion injury by regulating oxidative stress[J].Exp Ther Med,2024,27(4):154-163. [14] Ilhan I,Asci H,Tepebasi MY,et al.Selenium exerts protective effects on inflammatory cardiovascular damage:molecular aspects via SIRT1/p53 and Cyt-c/Cas-3 pathways[J].Mol Biol Rep,2023,50(2):1627-1637. [15] 杨春,徐玲玲,万春晓.急性脑梗死患者静脉溶栓前后氧化应激表达与功能结局的相关性[J].重庆医学,2022,51(6):910-915.
2025, Vol. 31 
冀公网安备13080202000786号