Abstract:Objective: To observe the relationship between elderly sarcopenia and swallowing dysfunction and analyze the effect of hyperbaric oxygen (HBO) adjuvant therapy. Methods: Totally 120 elderly patients with sarcopenia in the hospital from January 2022 to December 2023 were selected as the research subjects, and they received water swallow test. The occurrence of swallowing dysfunction was observed. The elderly patients with sarcopenia complicated with swallowing dysfunction were randomized into two groups. The control group adopted neuromuscular electrical stimulation, whereas the observation group received HBO adjuvant therapy on the basis of the control group. The levels of serum nutritional indexes [albumin (ALB), transferrin (TF)], modified Mann assessment of swallowing ability (MMASA), functional oral intake scale (FOIS) and swallowing-quality of life questionnaire (SWAL-QOL) were compared between groups at different time points. Results: Among the 120 elderly patients with sarcopenia, 66 cases were combined with dysphagia, the detection rate was 55.00%. 66 elderly patients with sarcopenia complicated with swallowing dysfunction were divided into control group (n=33) and observation group (n=33) by simple randomization method. At 3 weeks of treatment and at the end of treatment, serum ALB and TF levels in both groups were risen compared with those before treatment (P<0.05). The level of serum ALB in the observation group was higher than that in the control group at 3 weeks of treatment (P<0.05), and serum TF level was not statistically different from that in the control group (P>0.05), and the levels of serum ALB and TF at the end of treatment were higher compared with those in the control group (P<0.05). The swallowing function-related scores (MMASA, FOIS, SWAL-QOL) in both groups were enhanced at 3 weeks of treatment and at the end of treatment compared with those before treatment, and the observation group had higher scores (P<0.05). Conclusion: Elderly patients with sarcopenia are prone to swallowing dysfunction. After HBO adjuvant therapy, the swallowing function and nutritional status of elderly sarcopenia patients with swallowing dysfunction are significantly improved.
[1] Krenovsky J P,Btzel K,Ceballos-Baumann A,et al.Interrelation between sarcopenia and the number of motor neurons in patients with parkinsonian syndromes[J].Gerontology,2020,66(4):409-415. [2] 黄欢欢,陈治宇,谭雨龙,等.热休克蛋白与老年肌少症关系的研究进展[J].中国骨质疏松杂志,2023,29(5):771-775. [3] 王东凡,孔超,王鹏,等.肌少症对老年患者脊柱手术预后影响的研究进展[J].中国脊柱脊髓杂志,2022,32(1):85-88. [4] Vermaire J A,Raaijmakers C P J,Monninkhof E M,et al.Factors associated with swallowing dysfunction in patients with head and neck cancer[J].Oral diseases,2022,29(5):1937-1946. [5] King S N,Hurley J,Carter Z,et al.Swallowing dysfunction following radiation to the rat mylohyoid muscle is associated with sensory neuron injury[J].Journal of Applied Physiology,2021,130(4):1274-1285. [6] Hirata A,Ishizaka M,Sawaya Y,et al.Relationship between the swallowing function,nutritional status,and sarcopenia in elderly outpatients[J].The Japan Geriatrics Society,2021,58(1):134-142. [7] 江先福,林锦乐,胡建刚,等.小剂量静脉溶栓桥接血管内再通联合早期高压氧治疗醒后缺血性脑卒中[J].中国中西医结合急救杂志,2022,29(1):57-62. [8] 钟文,任燕怡,张宏,等.肌少症诊断与治疗新进展[J].中华老年医学杂志,2015,34(5):467-471. [9] 李全,张静,吴洪芸,等.口腔癌曼恩吞咽功能量表中文版的修订及信效度检验[J].中华口腔医学杂志,2021,56(9):914-919. [10] Matsuda Y,Karino M,Kanno T.Relationship between the functional oral intake scale (FOIS) and the self-efficacy scale among cancer patients:a cross-sectional study[J].Healthcare,2020,8(3):269. [11] Kim H J,Alluri R,Stein D,et al.Effect of topical steroid on swallowing following ACDF:results of a prospective double-blind randomized control trial[J].Spine,2021,46(7):413-420. [12] Okada T,Yamaguchi H,Tanaka,et al.Hand grip strength assessment based on sarcopenia diagnostic criteria predicts swallowing function[J].Dysphagia,2024,39(2):223-230. [13] 王鸣鸿,鲍晓,李芳,等.间歇性管饲结合高压氧治疗对脑卒中后吞咽障碍患者的临床疗效观察[J].中华航海医学与高气压医学杂志,2020,27(6):699-703. [14] 赵萍,赵书敏,曹会芳,等.穴位按摩联合高压氧对急性脑卒中后吞咽功能障碍临床效果[J].现代生物医学进展,2020,20(7):1385-1388.