Application of the Radial Dorsal Digital Artery Perforator Pedicled Propeller Flap in the Repair of Finger Skin Defects Patients and Its Effect on Serum Levels of IL-6 TNF-α and IL-8
LI Shouxi, ZHANG Liangyin, LYU Changju, et al
Baiyin First People's Hospital, Gansu Baiyin 730900, China
Abstract：Objective: To investigate the application effect of perforator pedicled propeller flap (PPPF) with radial dorsal digital artery in repairing skin defects of the fingers and its influence on serum levels of interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-8 (IL-8). Methods: A retrospective analysis was conducted on the clinical data of 80 patients with finger skin defects admitted to The 1st People's Hospital of Baiyin from March 2020 to March 2024. According to the surgical plan, they were divided into an observation group (n=40) and a control group (n=40), and underwent radial dorsal finger artery PPPF repair and conventional radial dorsal skin flap repair, respectively. The two groups were statistically analyzed in terms of perioperative indicators, serum IL-6, TNF - α, IL-8 levels, peripheral blood circulation indicators, hand function related indicators, complications, and satisfaction with finger cosmetic procedures. Results: The observation group had a shorter wound healing time, hospitalization time, and antibacterial drug use time than the control group, and a lower two-point discrimination than the control group (P<0.05). The levels of serum IL-6, TNF-α, and IL-8 in the observation group were lower than those in the control group on postoperative days 3 and 7 (P<0.05). At 3 and 6 months post-surgery, the observation group exhibited higher tissue partial pressure of oxygen (TcPO2), blood perfusion, Michigan Hand Function Questionnaire (MHQ) scores, and total finger joint mobility compared to the control group. Additionally, the cold intolerance symptom severity (CISS) score was lower in the observation group than in the control group (P<0.05). The complication rate in the observation group was lower than that in the control group 6 months after surgery, and the cosmetic satisfaction rate of the affected fingers was higher than that in the control group (P<0.05). Conclusion: The use of the radial dorsal digital artery PPPF to repair skin defects in fingers can reduce inflammatory reactions, promote wound healing, improve blood flow in the affected finger, restore hand function, reduce the risk of complications, and improve cosmetic satisfaction in the affected finger.
李守玺, 张亮银, 吕长举, 朱沛, 张正鹏, 王冰. 桡背侧指动脉穿支螺旋桨皮瓣修复在手指皮肤缺损患者应用及对血清IL-6 TNF-α IL-8的影响[J]. 河北医学, 2025, 31(9): 1502-1508.
LI Shouxi, ZHANG Liangyin, LYU Changju, et al. Application of the Radial Dorsal Digital Artery Perforator Pedicled Propeller Flap in the Repair of Finger Skin Defects Patients and Its Effect on Serum Levels of IL-6 TNF-α and IL-8. HeBei Med, 2025, 31(9): 1502-1508.
[1] Zyluk A,Flicinski F.Outcomes of coverage of soft tissue defects in the thumb with a "kite flap"[J].Handchir Mikrochir Plast Chir,2023,55(1):47-52. [2] 王自方,明立功,明立阳,等.重建感觉的第1掌骨桡背侧动脉皮支链皮瓣修复拇指末节软组织缺损[J].中华显微外科杂志,2024,47(3):325-327. [3] 冷双芝,薛德磊,宗民.两种桡背侧指动脉穿支皮瓣修复指端缺损的疗效比较[J].中国现代手术学杂志,2024,28(6):469-475. [4] 高子浚,张皓,李春霖,等.氧化应激影响移植后皮瓣愈合的研究进展[J].国际骨科学杂志,2021,42(1):35-39. [5] Zhou ZG,Yu LB,Meng FB,et al.Study on blood circulation monitoring after the tissue transfer of ultrathin or conventional anterolateral thigh flaps[J].Plast Reconstr Surg Glob Open,2024,12(11):6337. [6] 周洪翔,钟林,何亮,等.Flow-through桥式股前外侧皮瓣修复复杂小腿软组织缺损[J].中国修复重建外科杂志,2023,37(4):482-487. [7] Shetty PN,Hawken J,Sanghavi KK,et al.Correlation of patient-reported outcomes measurement information system questionnaires with the brief michigan hand questionnaire in patients with 5 common hand conditions[J].Hand Surg Am,2021,46(8):709. [8] 陈洪湖.桡背侧指动脉穿支螺旋桨皮瓣与常规桡背侧皮瓣修复拇指指端缺损的效果比较[J].中国民康医学,2023,35(13):163-165,169. [9] 王维顺,仲朝光,黄建军,等.穿支皮瓣修复术治疗手外伤软组织缺损患者的效果分析[J].中国实用医药,2023,18(8):21-24. [10] 韩健,陈懿,王洪凯,等.指动脉终末背侧穿支螺旋桨皮瓣修复指端缺损[J].中华手外科杂志,2020,36(6):471-472. [11] Bovill J,Huffman S,Cach G,et al.Propeller perforator flaps used for hand and digit reconstruction:a systematic review[J].Hand Microsurg,2024,16(2):100035.
2025, Vol. 31 
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