肺癌患者血清心肌肌钙蛋白水平与临床病理参数特征及预后关系分析

doi:10.3969/j.issn.1006-6233.2025.11.014

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摘要 目的: 分析肺癌患者血清心肌肌钙蛋白I(cTnI)水平与临床病理特征及预后的关系,评价cTnI对其预后的预测价值。方法: 将2020年1月至2023年1月于本院接受化疗的107例肺癌手术患者依据其1年内预后情况分为预后良好组(n=50)和预后不良组(n=57)。化疗结束后均测定其血清cTnI水平,比较不同病理特征及预后患者血清cTnI水平,以ROC曲线分析血清cTnI水平对患者预后的预测价值。结果: 血清cTnI水平与肺癌患者的淋巴结转移和TNM分期有关(P<0.05),与年龄、性别、病理类型、肿瘤直径、浸润深度无关(P>0.05);预后不良组的血清cTnI水平高于预后良好组(P<0.05)。ROC曲线显示,血清cTnI水平预测肺癌患者不良预后的曲线下面积(AUC)为0.862,灵敏度为66.67%,特异度为96.00%。结论: 肺癌化疗患者cTnI水平与其淋巴结转移、TNM分期及预后密切相关,化疗早期测定血清cTnI水平,可为患者的预后提供预测价值。

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	孙瑞洁
	吴春明
	汪奕珉

关键词 ：肺癌, 肌钙蛋白T, 临床病理特征

Abstract：Objective: To analyze the relationship of serum cardiac troponin I(cTnI) level with clinicopathological characteristics and prognosis in patients with lung cancer, and to evaluate the predictive value of cTnI on the prognosis. Methods: A total of 107 patients with lung cancer who received chemotherapy in the hospital from January 2020 to January 2023 were classified into a good prognosis group (n=50) and a poor prognosis group (n=57) according to the prognosis status within 1 year. After the end of chemotherapy, the serum cTnI levels of all patients were measured. The serum cTnI levels of patients with different pathological characteristics and prognosis were compared, and the predictive value of serum cTnI levels for the prognosis of patients was analyzed by ROC curve. Results: Serum cTnI level was correlated with lymph node metastasis and TNM staging (P<0.05), and there was no correlation with age, sex, pathological type, tumor diameter, or depth of invasion (P>0.05). The serum cTnI level in the poor prognosis group was higher than that in the good prognosis group (P<0.05). The ROC curve shows that the area under the curve (AUC) of serum cTnI level for predicting poor prognosis in lung cancer patients is 0.862, with a sensitivity of 66.67% and a specificity of 96.00%. Conclusion: The level of cTnI in patients with lung cancer undergoing chemotherapy is closely related to lymph node metastasis, TNM staging, and prognosis. The determination of serum cTnI level in the early stage of chemotherapy can provide predictive value on the prognosis of patients.

Key words： Lung cancer Cardiac troponin I Clinicopathological characteristics

基金资助:2022年安徽省重点研究与开发计划项目,(编号:2022e07020011)

引用本文:

孙瑞洁, 吴春明, 汪奕珉. 肺癌患者血清心肌肌钙蛋白水平与临床病理参数特征及预后关系分析[J]. 河北医学, 2025, 31(11): 1844-1848.
SUN Ruijie, WU Chunming, WANG Yimin. Analysis of the Relationship of Serum Cardiac Troponin Levels with Clinicopathological Parameter Characteristics and Prognosis in Patients with Lung Cancer. HeBei Med, 2025, 31(11): 1844-1848.

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