Analysis of the Effect and Efficacy of Endoscopic Combined with Drug/Interventional Therapy on MAP CVP and Blood Lactate Levels in Patients with Upper Gastrointestinal Bleeding and Hemorrhagic Shock
GAN Xiaojuan, XU Shanshan, GAO Fengjuan, et al
The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Urumqi 830054, China
Abstract：Objective: To explore the influence and efficacy of endoscopy combined with drug/interventional therapy on MAP, CVP and blood lactate levels in patients with upper gastrointestinal bleeding and hemorrhagic shock. Methods: A total of 135 patients with hemorrhagic shock caused by upper gastrointestinal bleeding who were treated in the First Affiliated Hospital of Xinjiang Medical University (Emergency and Trauma Center) from February 2022 to February 2024 were selected and randomly divided into a control group of 71 cases and a combined group of 64 cases. The control group received endoscopic treatment alone, while the combined group received endoscopic treatment combined with drug/interventional therapy. The hemostasis time,fluid infusion volume, prothrombin time, hospital stay, clinical efficacy, hemodynamic indicators and metabolic indicators (mean arterial pressure, central veno-us pressure, blood lactate), rebleeding rate, and complication rate (perforation, infection, thrombosis) were compared between the two groups. Results: The combined group demonstrated a higher total effective rate compared to the control group. Meanwhile, indicators including hemostasis duration, fluid infusion volume, prothrombin time, hospitalization stay length, rebleeding rate, and complication incidence were all lower in the combined group than in the control group. The MAP and blood lactate levels of patients in the combined group were decreased, and the CVP level was increased (P<0.05). The difference in MAP and CVP before and after treatment in the combined group was higher than that in the control group (P<0.05). The difference in blood lactate levels before and after treatment in the combined group was higher than that in the control group, but the difference was not statistically significant (P>0.05). Conclusion: Endoscopic treatment combined with drug/interventional therapy can effectively control bleeding, improve coagulation and metabolic status, reduce risks, and ensure patient safety.
甘晓娟, 许姗姗, 高凤娟, 董辉, 马宏飞. 内镜联合药物/介入治疗对上消化道出血失血性休克患者 MAP CVP 及血乳酸水平的影响与疗效分析[J]. 河北医学, 2025, 31(11): 1880-1883.
GAN Xiaojuan, XU Shanshan, GAO Fengjuan, et al. Analysis of the Effect and Efficacy of Endoscopic Combined with Drug/Interventional Therapy on MAP CVP and Blood Lactate Levels in Patients with Upper Gastrointestinal Bleeding and Hemorrhagic Shock. HeBei Med, 2025, 31(11): 1880-1883.
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