肝素结合蛋白白细胞分化抗原6项与学龄前期小儿肺炎病情严重程度和预后的关系及临床价值

doi:10.3969/j.issn.1006-6233.2025.11.021

摘要
图/表
参考文献
相关文章 (6)

全文: PDF (1507 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要 目的: 探究肝素结合蛋白(HBP)、白细胞分化抗原6项与学龄前期小儿肺炎病情严重程度和预后的关系。方法: 以2023年11月至2024年10月本院收治的120例学龄前期小儿肺炎患儿为研究对象,其中轻症组86例,重症组34例,另依据预后情况分为预后良好组(n=95)与预后不良组(n=25)。测定所有研究对象的血清HBP、白细胞分化抗原6项[T淋巴细胞(CD3%)、辅助/诱导性T细胞(CD4%)、抑制/杀伤性T细胞(CD8%)、CD4/CD8、B淋巴细胞(CD19%)、NK细胞(CD16+CD56%)]水平。以Logistic回归分析HBP、白细胞分化抗原与学龄前期小儿肺炎患儿病情严重程度和预后的关系;以ROC曲线分析HBP、白细胞分化抗原对患儿病情和预后的评估价值。结果: 重症组的血清HBP水平高于轻症组,CD3%、CD4%、CD4/CD8、CD19%、CD16+CD56%水平低于轻症组(P<0.05);两组间CD8%水平比较差异无统计学意义(P>0.05)。预后不良组的血清HBP水平高于预后良好组,CD3%、CD4%、CD4/CD8、CD19%、CD16+CD56%水平低于预后良好组(P<0.05);两组间CD8%水平比较差异无统计学意义(P>0.05)。Logistic回归分析显示,血清HBP水平升高、CD3%、CD4%、CD4/CD8、CD19%、CD16+CD56%水平降低是学龄前期小儿肺炎患儿病情严重程度和预后不良的危险因素(P<0.05);ROC曲线显示,血清HBP、CD3%、CD4%、CD4/CD8、CD19%、CD16+CD56%联合评估患儿病情严重程度的AUC为0.935,灵敏度为100.00%,特异度为79.07%;联合评估患儿预后的AUC为0.948,灵敏度为92.00%,特异度为90.53%;联合评估效能均优于各指标单独评估(P<0.05)。结论: HBP、白细胞分化抗原与学龄前期小儿肺炎患儿病情严重程度和预后密切关联,通过联合测定各指标可为临床评估患儿的病情严重程度和预后提供参考价值。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章
	陈飞飞
	朱峰
	王宗燕

关键词 ：小儿肺炎, 肝素结合蛋白, 白细胞分化抗原

Abstract：Objective: To explore the relationship between heparin-binding protein (HBP) and 6 items of leukocyte differentiation antigens and disease severity and prognosis in preschool children with pediatric pneumonia. Methods: Totally 120 preschool children with pediatric pneumonia admitted to the hospital from November 2023 to October 2024 were selected as research subjects, including 86 cases in the mild group and 34 cases in the severe group. According to the prognosis status, the enrolled patients were classified into good prognosis group (95 cases) and poor prognosis group (25 cases). Serum HBP and 6 items of leukocyte differentiation antigens [T lymphocyte (CD3%), helper/inducible T cell (CD4%), suppressor/killer T cell (CD8%), CD4/CD8, B lymphocyte (CD19%), NK cell (CD16+CD56%)] were measured in all subjects. The relationship of HBP and leukocyte differentiation antigens with disease severity and prognosis in preschool children with pneumonia was explored by Logistic regression analysis. ROC curve was adopted to analyze the evaluation value of HBP and leukocyte differentiation antigens on disease condition and prognosis. Results: Serum HBP level in the severe group was higher while the levels of CD3%, CD4%, CD4/CD8, CD19% and CD16+CD56% were lower than those in the mild group (P<0.05). There was no statistically significant difference in the CD8% level between the two groups (P>0.05). The level of serum HBP in the poor prognosis group was higher than that in the good prognosis group while the levels of CD3%, CD4%, CD4/CD8, CD19% and CD16+CD56% were lower (P<0.05). There was no statistically significant difference in the CD8% level between the two groups (P>0.05). Logistic regression analysis suggested that elevated serum HBP level and decreased CD3%, CD4%, CD4/CD8, CD19% and CD16+CD56% were risk factors of disease severity and poor prognosis in preschool children with pediatric pneumonia (P<0.05). ROC curve found that the AUC, sensitivity and specificity of combination of serum HBP, CD3%, CD4%, CD4/CD8, CD19% and CD16+CD56% were 0.935, 100.00% and 79.07% in evaluating the disease severity of children, and were 0.948, 92.00% and 90.53% in evaluating the prognosis of children. The efficiency of combined evaluation was better than that of each indicator alone (P<0.05). Conclusion: HBP and leukocyte differentiation antigens are closely associated with the disease severity and prognosis in preschool children with pediatric pneumonia. The combined determination of various indicators can provide reference value for clinical evaluation of disease severity and prognosis of children.

Key words： Pediatric pneumonia Heparin-binding protein Leukocyte differentiation antigens

基金资助:安徽省临床医学研究转化专项,(编号:202304295107020119)

通讯作者: 朱峰

引用本文:

陈飞飞, 朱峰, 王宗燕. 肝素结合蛋白白细胞分化抗原6项与学龄前期小儿肺炎病情严重程度和预后的关系及临床价值[J]. 河北医学, 2025, 31(11): 1884-1890.
CHEN Feifei, ZHU Feng, WANG Zongyan. Relationship and Clinical Value of Heparin-Binding Protein and Six Items of Leukocyte Differentiation Antigens with Disease Severity and Prognosis of Pediatric Pneumonia in Preschool Children. HeBei Med, 2025, 31(11): 1884-1890.

链接本文:

http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2025.11.021 或 http://www.hbyxzzs.cn/CN/Y2025/V31/I11/1884

[1] Ding N,Liu D,Duan X,et al.Twist2 reduced NLRP3-induced inflammation of infantile pneumonia via regulation of mitochondrial permeability transition by FOXO1[J].Int Arch Allergy Immunol,2022,183(10):1098-1113.
[2] Ding N,Meng Y,Liu L,et al.Sphingosine Kinase-1 (SPHK1) promotes inflammation in infantile pneumonia by regulating NLRP3 inflammasome and SIRT1 expression[J].Histol Histopathol,2022,37(12):1227-1240.
[3] Yu Y,Yang T,Ding Z,et al.Circ_0026579 alleviates LPS-induced WI-38 cells inflammation injury in infantile pneumonia[J].Innate Immun,2022,28(1):37-48.
[4] Acar T,Ertekin B,Yortanli M,et al.Prognostic value of heparin-binding protein for mortality in severe COVID-19 pneumonia[J].Biomark Med,2022,16(13):981-991.
[5] Li Y,Wu M,Liang Y,et al.Mycoplasma pneumoniae infection outbreak in Guangzhou,China after COVID-19 pandemic[J].Virol,2024,21(1):183-193.
[6] 江载芳,申昆玲,沈颖.诸福棠实用儿科学[M].第8版.北京:人民卫生出版社,2015.1253-1262.
[7] Chen L,Chen Y,Huang J,et al.LncRNA LINC00707 serves as a sponge of miR-382-5p to alleviate lipopolysaccharide (LPS)-induced WI-38 cell injury through upregulating NKAP in infantile pneumonia[J].Autoimmunity,2022,55(5):328-338.
[8] Xiao X,Hong Y,Wang S,et al.Diagnostic value of plasma heparin-binding protein and the heparin-binding protein-to-albumin ratio in patients with community-acquired Pneumonia:a retrospective study[J].BMC Infect Dis,2023,23(1):777-784.
[9] Khani L,Jazayeri MH,Nedaeinia R,et al.The frequencies of peripheral blood CD5+CD19+ B cells,CD3-CD16+CD56+ NK,and CD3⁺CD56+ NKT cells and serum interleukin-10 in patients with multiple sclerosis and neuromyelitis optica spectrum disorder[J].Allergy Asthma Clin Immunol,2022,18(1):5-14.
[10] 邵丽娇,王鑫,闫丽静,等.肝素结合蛋白联合炎性细胞因子在重症肺炎合并脓毒症患者预后评估中的价值[J].标记免疫分析与临床,2024,31(5):813-817,854.
[11] 马玉静,张伟,袁欣.脑卒中相关性肺炎的危险因素及血浆肝素结合蛋白水平对其预测价值[J].解放军医药杂志,2022,34(6):92-95,99.
[12] 黄晓茹,陈杭,林珊,等.各型支气管肺炎患儿淋巴细胞亚群的变化及价值[J].检验医学与临床,2022,19(17):2366-2369.
[13] 邓龙,王冉,赵文俊,等.肝素结合蛋白对社区获得性肺炎诊断价值及预后评估[J].蚌埠医学院学报,2022,47(5):600-602,607.
[14] Yang Y,Huang J,Yan H,et al.Decreased NK cells in cases of severe adenovirus pneumonia with liver dysfunction in pediatric intensive care unit:Evidence from 330 patients[J].Allergol Immunopathol (Madr),2023,51(3):42-48.