|
|
|
| Curative Effect of Folic Acid Combined with Vitamin B12 in Treating Senile Coronary Heart Disease with Chronic Heart Failure and Homocysteinemia |
| ZHANG Zedan, ZENG Li, TAN Ping |
| Fuzhou General Hospital, Fujian Fuzhou 350025, China |
|
|
|
|
Abstract Objective: To investigate the efficacy of folic acid and vitamin B12 in the treatment of elderly patients with chronic heart failure and hyperhomocysteinemia. Methods: A total of 80 elderly patients with CHD with hyperhomocysteinemia who were hospitalized from June 2015 to June 2017 were randomly divided into two groups. The patients in the control group were given symptomatic treatment while the patients in the experimental group Folic acid and vitamin B12 were used to compare disease-related parameters, heart failure grade and quality of life in both groups. Results: The levels of HCY, NT-proBNP, TG, TC, LDL-C, MCP-1 and IL-8 in the experimental group were significantly lower than those in the control group (P <0.01). The NYHAⅠ ~ Ⅱlevel after treatment was significantly higher than that of the control group Group, there was a significant difference (P <0.05). Conclusion: The effect of folic acid combined with vitamin B12 in the treatment of chronic heart failure and hyperhomocysteinemia in elderly patients with coronary heart disease is significant, and it is of reference significance.
|
|
|
|
|
|
[1] 王婷婷,李辉,范建国,等.老年慢性心力衰竭患者甲状腺激素和同型半胱氨酸水平与心功能关系的研究[J].中国血液流变学杂志,2016,26(2):227~229.
[2] 梁雪,张佩生,高瑜.老年慢性心力衰竭患者血清中亲环素、内皮素-1、同型半胱氨酸和半胱氨酸蛋白酶抑制剂C的表达及意义[J].中国老年学杂志,2013,33(15):3732~3733.
[3] Care I F Q A.Systematic guideline search and appraisal,as well as extraction of relevant recommendations,for a DMP"chronic heart failure"[M].Cologne,Germany:Institute for Quality and Efficiency in Health Care(IQWiG),2015.
[4] 曾军,王一波,孙立民,等.慢性心力衰竭患者N端脑钠肽前体和血清同型半胱氨酸测定的临床意义[J].临床荟萃,2013,28(2):199~200.
[5] Xia T,Chai X,Shen J.Pancreatic exocrine insufficiency in patients with chronic heart failure and its possible association with appetite loss[J].PLoS One,2017,12(11):e187804.
[6] 蔡宏文,李洋威,吕淑敏,等.慢性心力衰竭中医辨证分型与血清胱抑素C及同型半胱氨酸的相关性研究[J].中国中西医结合急救杂志,2014,21(5):386~388.
[7] 雷登顺.探讨同型半胱氨酸和高敏C反应蛋白作为慢性心力衰竭危险因子的临床意义[J].中国实验诊断学,2013,17(8):1434~1436.
[8] 罗春苗,高潮,冯俊.同型半胱氨酸及脑钠肽水平与慢性心力衰竭危险分级的相关性分析[J].中国循证心血管医学杂志,2016,8(3):280~282.
[9] Brugts J J,Manintveld O C,van Mieghem N.Remote monitoring of pulmonary artery pressures with cardioMEMS in patients with chronic heart failure and NYHA class III:first experiences in the netherlands[J].Neth Heart,2017.
[10] Tavazzi L.It's time to move on from counting co-morbidities to curing them:the case of chronic heart failure-chronic obstructive pulmonary disease co-morbidity[J].Eur Heart Fail,2017.
[11] 唐细田,肖琳.同型半胱氨酸与慢性心力衰竭严重程度及近期预后相关性分析[J].实验与检验医学,2014,32(5):618~619.
[12] 吴波,吴海声,陈云华,等.亚临床甲减对老年慢性心力衰竭患者心功能和脑钠肽及同型半胱氨酸的影响[J].中国老年学杂志,2016,36(18):4630~4631.
[13] 邱艳,洪鹭蓉,林娟.叶酸、B族维生素对老年慢性心力衰竭伴高同型半胱氨酸血症患者心室重构及心功能的影响[J].实用心脑肺血管病杂志,2012,20(2):244~245.
[14] Zheng C,Li M,Kawada T,et al.Frequent drinking of small volumes improves cardiac function and survival in rats with chronic heart failure[J].Physiol Rep,2017,5(21).
[15] 余木生,熊春霖,许通文.叶酸、维生素B12治疗对慢性心力衰竭伴高同型半胱氨酸血症患者心功能的影响[J].海南医学,2017,27(8):1237~1239.
[16] Wizner B,Fedyk-Lukasik M,Opolski G,et al.Chronic heart failure management in primary healthcare in poland:results of a nationwide cross-sectional study[J].Eur Gen Pract,2017,1~8.
[17] Maru S,Byrnes J,Carrington M J,et al.Economic evaluation of a nurse-led home and clinic-based secondary prevention programme to prevent progressive cardiac dysfunction in high-risk individuals:the nurse-led intervention for less chronic heart failure(NIL-CHF) randomized controlled study[J].Eur Cardiovasc Nurs,2017,1305419627.
[18] 卫亚丽,赵玉英,丁超,等.叶酸联合维生素B12治疗老年冠心病慢性心力衰竭伴高同型半胱氨酸血症的疗效观察[J].中西医结合心脑血管病杂志,2017,15(6):709~711. |
|
|
|
2018, Vol. 24 
