急性缺血性脑卒中患者血清Sestrin2水平与病情严重程度及预后的相关性分析

doi:10.3969/j.issn.1006-6233.2019.02.022

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Abstract Objective: To analyze the relationship between the serum level of Sestrin2 and the severity and prognosis of acute ischemic stroke (AIS). Methods: A total of 98 patients with AIS who were admitted to the hospital during the period from January 2017 to January 2018 were included in the case group, and 40 persons who underwent physical examination in the same period were included in the control group. Serum Sestrin2 levels were determined by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). According to the National Institute of Health Stroke Scale (NIHSS), the patients were divided into mild, moderate and severe three subgroups. According to the modified Rankin (mRS) score at 3 months after discharge, the patients were divided into good prognosis group and poor prognosis group. The serum Sestrin2 levels were compared between subgroups. Results: The level of serum Sestrin2 in the case group was significantly higher than that in the control group [(13.90±2.54) ng/mL vs (11.76±1.41) ng/mL] (P<0.05). There were significant differences in serum Sestrin2 levels among the mild, moderate and severe groups (P<0.05), but there was no significant difference in the serum Sestrin2 level between the good prognosis group and the poor prognosis group [(13.69±1.95) ng/mL vs (14.60±2.38) ng/mL] (P>0.05). The serum Sestrin2 level was positively correlated with the NIHSS score (P<0.05) but not correlated with the mRS score (P>0.05). Conclusion: The level of serum Sestrin2 in patients with AIS is related to the severity of the disease, but there is no significant correlation with the prognosis.

Key words： Acute ischemic stroke Sestrin2 Severity Prognosis

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	ZHANG Jinzhi
	WANG Lijuan
	ZHANG Xiao

Cite this article:

ZHANG Jinzhi,WANG Lijuan,ZHANG Xiao. Correlation of Serum Sestrin2 levels with Severity and Prognosis of Acute Ischemic Stroke[J]. HeBei Med, 2019, 25(2): 259-261.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2019.02.022 OR http://www.hbyxzzs.cn/EN/Y2019/V25/I2/259

[1] 冯曼玲.血浆脑利钠肽和超敏C反应蛋白对急性缺血性脑卒中患者预后的评估价值[J].标记免疫分析与临床,2015,22(3):164~166.
[2] Zhang J H,Shi X,Xu L,et al.Sestrins:A new kid for stroke treatment[J].Curr Drug Deliv,2017,14(6):797~806.
[3] 中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志,2010,43(2):146~153.
[4] Moniche F,Montaner J,Gonzalez-Marcos J R,et al.Intra-arterial bone marrow mononuclear cell transplantation correlates with GM-CSF,PDGF-BB,and MMP-2 serum levels in stroke patients:results from a clinical trial[J].Cell Transplant,2014,23(1):S57~64.
[5] Hao B B,Pan X X,Ye F,et al.Oleanolic acid attenuates liver ischemia reperfusion injury by HO-1/Sesn2 signaling pathway[J].Hepatobiliary Pancreat Dis Int,2016,15(5):519~524.
[6] Papadia S,Soriano F X,LéveilléF,et al.Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses.[J].Channels,2009,11(4):476~487.
[7] Morrison A,Chen L,Wang J,et al.Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart[J].Faseb J,2015,29(2):408~417.
[8] 翟晓斌,葛朝明,范祯祯,等.急性缺血性卒中患者血清Ox-LDL水平与疾病严重程度及预后的相关性[J].中国循证心血管医学志,2016,8(4):436~438.
[9] 胡永亮,谭启杏,王红丽,等.Sestrin2通过抑制砷化物诱导的氧化应激反应发挥拮抗细胞凋亡的保护性作用[J].生物技术讯,2016,27(3):314~317.
[10] 郭明,夏中元.Sestrin2抗氧化应激作用在缺血再灌注中的研究进展[J].中国医药导报,2017,14(17):28~31.
[11] Shi X,Doycheva DM,Xu L,et al.Sestrin2 induced by hypoxia inducible factor1 alpha protects the blood-brain barrier via inhibiting VEGF after severe hypoxic-is chemic injury in neonatal rats[J].Neurobiol Dis,2016,95(1):111~121.