|
|
|
| Clinical Characteristics Analysis and the Change of Serums IL-6 and C-reactive Protein in Children with Henoch-Schonlein Purpura |
| ZHENG Zhifang, CHEN Guoli, SUN Peng |
| The Affiliated Hospital of Chengde Medical University, Hebei Chengde067000, China |
|
|
|
|
Abstract Objective:To study the clinical characteristics and to investigate the changes of serum levels of IL-6 and CRP in children of Henoch-Schonlein purpura(HSP). Methods:The 126 cases with HSP treated from June 1, 2015 to May 31, 2017, which were selected as the research objects, were divided into the group of patients with simple HSP (74 cases) and patients with HSP nephritis (52 cases) . All patients were retrospectively studied and clinical manifestations, cause of before the onset and starting symptoms. Meanwhile, the other 100 healthy medical examination children in our hospital during the same period were selected as the control group. The levels of IL-6 and CRP in the control group and experimental group were detected respectively. Results:①In the 126 cases of children with HSP, the average age of was 5.87±2.23 years old, from three to seven years old was accounted for 77.78%, and minimum age was 1 year 6 months. ②Infection was the major factor to induce HSP (55.56%); and food allergy was the second factor(14.29%). ③For starting symptoms, skin purpura was found in 78(61.90%) patients, which was for the first in HSP, especially for double lower limbs purpura. Renal involvement was found in 52(41.27%) patients. ④Serum levels of IL-6 and CRP of the patients with HSP before the treatment were higher than those of the normal control group(P<0.05). Serum levels of IL-6 and CRP were significantly higher in the patients with HSP nephritis than those in patients with simple HSP(P<0.05). The early disease recovery, levels of IL-6 and CRP were falling in the patients with HSP nephritis, but also higher than those of in patients with simple HSP(P<0.05). Conclusion:①The onset age of HSP was among school-age children and the most important inducing factor was infection. ②IL-6 and CRP participated in the pathological process of HSP, and dynamic testing the changing of levels of IL-6 and CRP in HSP could provide theoretical basis for clinical judgment condition.
|
|
|
|
|
|
[1] 陈朋,肖风丽.过敏性紫癜病因及发病机制研究[J].实用皮肤病学杂志,2011,4(2):93~95.
[2] 中华医学会儿科学分会免疫学组.2013儿童过敏性紫癜询证诊治建议[J].中华儿科杂志,2013,51(7):502~507.
[3] Hwang HH, Lim IS, Choi BS, et al. Analysis of seasonal tendencies in pediatric Henoch-Schonlein purpura and comparison with outbreak of infectious diseases[J].2018, 97(36): e12217.
[4] 张碧丽,王文红,范树颖.儿童过敏性紫癜575例分析[J].中华儿科杂志,2001,39(11):646~649.
[5] Pillebout E, Jamin A, Ayari H, et al. Biomarkers of IgA vasculitis nephritis in children[J]. PLoS One,2017, 12(11):e0188718.
[6] Chang H, Zhang QY, Lin Y, et al. Correlation of TLR2 and TLR4 expressions in peripheral blood mononuclear cells to Th1- and Th2-type immune responses in children with henoch-schonlein purpura[J].Int Clin Exp Med,2015, 8(8):13532~13539. |
|
|
|
2019, Vol. 25 
