肠道菌群代谢相关产物与6~9岁健康儿童骨骼肌质量的相关性分析

doi:10.3969/j.issn.1006-6233.2024.01.028

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Abstract Objective: To explore the correlation between gut microbiota metabolites, specifically short-chain fatty acids (SCFAs), and skeletal muscle mass in healthy children aged 6-9. Methods: This cross-sectional study was conducted from December 2021 to January 2023. A total of 176 participants (68 girls and 108 boys) were included in the study. Skeletal muscle mass indices were measured using dual-energy X-ray absorptiometry (DXA), and participants were stratified based on bone mineral density (BMD) values. The concentration of SCFAs in feces was determined using high-performance liquid chromatography (HPLC). Spearman correlation analysis was performed to assess the relationship between fecal SCFAs and skeletal muscle mass. Results: Based on TBLH bone density reference values, children included in the study were classified into normal BMD (Z score ≥ 0, n = 120) and low BMD (Z score < 0, n = 56) groups. Compared to the normal BMD group, the low BMD group showed significantly lower TB BMD, TBLH BMD, LS BMD, PELV BMD, TSM/TBF, ASM/AFM (P<0.05), and significantly increased TSM, ASM (P<0.05). The low BMD group had a significantly higher level of fecal butyric acid and significantly lower levels of acetic acid, propionic acid, total SCFAs compared to the normal BMD group (P<0.05). After adjusting for covariates and false discovery rate (FDR) correction, multivariate regression analysis showed a significant positive correlation between TBLH BMD, PELV BMD, and butyric acid, propionic acid, and total SCFAs (β=0.15~0.23, P<0.05). Conclusion: Fecal butyric acid, propionic acid, and total SCFAs are positively correlated with bone mineral density (BMD) in healthy children aged 6~9.

Key words： Short-chain fatty acids Children Bone mineral density Skeletal health

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.01.028 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I1/141

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