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| Clinical Significance of Interferon-γ FM and MP-Ab Detection in Children with Mycoplasma Pneumoniae Infection |
| GAO Lihua, ZHU Li, MAN Haixia |
| Anhui Provincial General Hospital of Armed Police, Anhui Hefei 230041, China |
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Abstract Objective: To investigate the clinical significance of interferon-γ (IFN-γ), fibrin monomer (FM), and Mycoplasma pneumoniae antibody (MP-Ab) detection in children with Mycoplasma pneumoniae infection. Methods: A total of 103 children with Mycoplasma pneumoniae pneumonia admitted to our hospital from November 2020 to November 2023 were enrolled as the study group. Sixty healthy children who underwent physical examination and showed normal results during the same period were selected as the control group. The serum levels of IFN-γ and FM and the contents of MP-Ab in the two groups were compared. The serum levels of IFN-γ, FM and the contents of MP-Ab in children with different disease severity in the observation group were compared. With pathological examination as the gold standard, the evaluation value of serum IFN-γ, FM and MP-Ab detection for Mycoplasma pneumoniae pneumonia was analyzed. Results: Among the 103 children with Mycoplasma pneumoniae pneumonia, 72 were in the acute stage and 31 were in the recovery stage. Among the 72 children in the acute stage, 18 had severe Mycoplasma pneumoniae pneumonia and 54 had mild Mycoplasma pneumoniae pneumonia. The serum levels of IFN-γ and FM and the contents of MP-Ab in the acute and recovery stages of the observation group were significantly higher than those in the control group, and the acute stage was significantly higher than the recovery stage (P<0.05). The serum levels of IFN-γ and FM and the contents of MP-Ab in children with severe Mycoplasma pneumoniae pneumonia in the acute stage were significantly higher than those in children with mild Mycoplasma pneumoniae pneumonia, and the differences were statistically significant (P<0.05). Conclusion: The levels of IFN-γ, FM and MP-Ab are highly expressed in children with Mycoplasma pneumoniae pneumonia and increase gradually with the aggravation of the disease. They have the potential to be applied to the early diagnosis and evaluation of the disease in children.
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2024, Vol. 30 
