LncRNA MALAT1 miR-143-3p在甲状腺癌组织中的表达水平及其临床意义

doi:10.3969/j.issn.1006-6233.2025.03.010

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Abstract Objective: To investigate and analyze the relative expression and clinical significance of long non coding RNA metastasis associated lung adenocarcinoma transcript 1 (LncRNA MALAT1) and microribonucleic acid (miR)-143-3p in thyroid cancer tissue. Methods: From September 2019 to February 2021, 102 patients with thyroid cancer admitted to our hospital were recruited. They were grouped into the survival group (n=71) and death group (n=31) based on their follow-up results. Real-time reverse transcription-polymerase chain reaction (RT-PCR) was applied to detect the relative expression levels of LncRNA MALAT1 and miR-143-3p in tissues. General clinical data and clinical pathological features were collected and analyzed. Pearson method was used to analyze the correlation between LncRNA MALAT1 and miR-143-3p. STARbase was employed to predict the targeting relationship between LncRNA MALAT1 and miR-143-3p. COX was performed to analyze the influencing factors of prognosis. K-M curve was plotted to analyze the relationship between LncRNA MALAT1, miR-143-3p and survival. Results: Compared with those of adjacent tissues, the relative expression level of LncRNA MALAT1 was significantly increased (P<0.05) and the relative expression level of miR-143-3p was significantly reduced in cancer tissues (P<0.05). The expression of LncRNA MALAT1 and miR-143-3p was related to tumor diameter, tumor-node-metastasis (TNM) stage, differentiation degree, and lymph node metastasis (P<0.05). There was a negative correlation between LncRNA MALAT1 and miR-143-3p (r=-0.408, P<0.05), and there was a targeting relationship between LncRNA MALAT1 and miR-143-3p. The differences were statistically significant in TNM staging, differentiation degree, lymph node metastasis, LncRNA MALAT1, and miR-143-3p expression between groups (P<0.05). Lymph node metastasis and increased expression of LncRNA MALAT1 were risk factors affecting patient prognosis (P<0.05), while miR-143-3p was a protective factor (P<0.05). The survival rate of patients with low expression of LncRNA MALAT1 was significantly higher than that of patients with high expression (80.85% [38/47] vs 60.00% [33/55] , χ²=6.597, P=0.010). The survival rate of patients with high expression of miR-143-3p was significantly higher than that of patients with low expression (81.63% [40/49] vs 58.49% [31/53], χ²=8.509, P=0.004). Conclusion: In thyroid cancer tissue, the relative expression of LncRNA MALAT1 increases and the relative expression of miR-143-3p decreases, which is related to clinical pathological characteristics and has a certain impact on prognosis.

Key words： Long non coding RNA metastasis associated lung adenocarcinoma transcript 1 Microribonucleic acid-143-3p Thyroid cancer

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	JIN Dong
	LIU Yongli

Cite this article:

JIN Dong,LIU Yongli. Expression Levels and Clinical Significance of LncRNA MALAT1 and miR-143-3p in Thyroid Cancer Tissue[J]. HeBei Med, 2025, 31(3): 408-414.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.03.010 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I3/408

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