Hcy HbA1c UA水平及联合检测对糖尿病视网膜病变发生的预测价值

doi:10.3969/j.issn.1006-6233.2025.07.019

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Abstract Objective: To explore the predictive value of Hcy, HbA1c, and UA levels and the combined detection of the occurrence of diabetic retinopathy (DR). Methods: A total of 118 patients with type 2 diabetes mellitus (T2DM) who were diagnosed in the hospital from June 2020 to June 2024 were selected. All patients completed an eye exam within 1-2 weeks of admission. Based on the results of ophthalmic examination, 118 patients were divided into DR group (n=62) and NDR group (n=56). Serum Hcy,HbA1c,UA levels in the two groups were detected, and the differences in clinical indicators between two groups were compared with univariate analysis. The independent correlation between Hcy,HbA1c,UA level and DR occurrence was evaluated with multivariate Logistic regression analysis, and the predictive value of Hcy,HbA1c,UA level on DR was assessed by receiver operating characteristic (ROC) curve. Results: Hcy level, intraocular pressure, HbA1c, and UA in the DR group were higher than those in the NDR group (P<0.05). Multivariate Logistic regression analysis showed that Hcy, HbA1c, and UA were the influential factors of diabetic retinopathy (P<0.05). ROC curve analysis indicated that the combined detection of Hcy, HbA1c, and UA had a higher predictive value for DR, with an area under the curve (AUC) of 0.830 (95%CI: 0.750-0.893), which was higher than single detection (Z/P=2.137/0.032, 4.527/<0.001, 2.879/0.004). The sensitivity was 90.32% and the specificity was 66.07%. Conclusion: The elevated levels of serum Hcy, HbA1c and UA are correlated with the occurrence of DR and have high predictive value. The above indicators can be used as potential early screening indicators for DR, which is helpful for clinical risk stratification and early intervention.

Key words： Type 2 diabetes mellitus Homocysteine Diabetic retinopathy Predictive value

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	WANG Chao
	DONG Chongzhou
	ZHANG Jielou
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WANG Chao,DONG Chongzhou,ZHANG Jielou, et al. Predictive Value of Hcy HbA1c and UA Levels and the Combined Detection of the Occurrence of Diabetic Retinopathy[J]. HeBei Med, 2025, 31(7): 1164-1169.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.07.019 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I7/1164

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