彩色多普勒超声血流参数与Her2阳性乳腺癌组织PI3K Akt表达及临床预后的关系

doi:10.3969/j.issn.1006-6233.2025.08.020

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Abstract Objective: To explore the relationship of color Doppler ultrasound blood flow parameters with expressions of tissue phosphatidylinositol 3-kinase (PI3K) and protein kinase B (Akt) and clinical prognosis in human epidermal growth factor receptor 2 (Her2)-positive breast cancer, and to evaluate the evaluation value on prognosis. Methods: Totally 103 patients with Her2-positive breast cancer who received treatment in the hospital from January 2020 to January 2023 were enrolled as study subjects. According to the prognosis status, the enrolled patients were divided into poor prognosis group (n=27) and good prognosis group (n=76). All subjects received color Doppler ultrasound examination to obtain blood flow parameters [resistance index (RI), pulsatility index (PI), peak flow rate (V_max)], and the expressions of PI3K and Akt in cancer tissues were determined. The correlation between PI, RI, V_max and Her2-positive breast cancer tissue PI3K and Akt expressions or prognosis was explored by Spearman correlation analysis. Receiver operating characteristic (ROC) curve was adopted to analyze the evaluation value of PI, RI and V_max on prognosis. Results: The RI, PI and V_max and positive expression rates of PI3K and Akt in the poor prognosis group were higher than those in the good prognosis group (P<0.05). Correlation analysis showed that PI, RI and V_max were positively correlated with Her2-positive breast cancer tissue PI3K expression and Akt expression and poor prognosis (rRI=0.284, 0.206, 0.443; rPI=0.213, 0.244, 0.464; rV_max=0.245, 0.221, 0.355, P<0.05). ROC curve suggested that the area under the curve (AUC), sensitivity and specificity of combination of RI, PI and V_max in evaluating the prognosis of patients with Her2-positive breast cancer were 0.919, 88.89% and 89.47%. The combined evaluation efficiency was better than that of each index alone (P<0.05). Conclusion: Blood flow parameters such as PI, RI and V_max are positively correlated with PI3K expression, Akt expression and poor prognosis in patients with Her2-positive breast cancer. Analyzing the above blood flow parameters can provide some reference value on the prognosis evaluation of patients, and guide the formulation of individualized treatment regimen.

Key words： Human epidermal growth factor receptor 2 Breast cancer Ultrasound blood flow parameters Phosphatidylinositol 3-kinase Protein kinase B

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	LI Xiaoxin
	JIN Xin
	WANG Pei
	et al

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LI Xiaoxin,JIN Xin,WANG Pei, et al. Relationship Between Color Doppler Ultrasonic Blood Flow Parameters and the Expression of PI3K and Akt in Her2-Positive Breast Cancer Tissues and Clinical Prognosis[J]. HeBei Med, 2025, 31(8): 1343-1348.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.08.020 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I8/1343

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