自体角膜缘干细胞移植联合羊膜覆盖对翼状胬肉切除患者的影响

doi:10.3969/j.issn.1006-6233.2025.08.022

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Abstract Objective: To investigate the influences of autologous limbal stem cell transplantation (LSCT) combined with amniotic membrane transplantation (AMT) on visual acuity recovery status and tear function in patients undergoing pterygium excision. Methods: A total of 102 patients who received pterygium excision in the hospital from January 2023 to October 2024 were selected as research subjects. Patients were divided into a control group and a combined group according to the simple randommethod using a random number table, with 51 cases in each group. The control group was treated with pterygium excision combined with LSCT, while the combined group was treated with AMT on the basis of the control group. The postoperative swelling time, congestion regression time, corneal epithelial healing time and postoperative recurrence rate and visual acuity recovery status [uncorrected visual acuity (UCVA), corneal astigmatism (CA)], tear secretion function [Schirmer test (SIT)], ocular surface conditions [noninvasive Keratograph tear breakup time (NIKBUT), tear meniscus height (MIKTMH)] and tear inflammatory factors [interleukin (IL)-1β, transforming growth factor (TGF)-β1] before surgery and at 2 weeks after surgery were compared between the groups. The incidence rates of postoperative complications and discomfort were recorded. Results: There were no statistical differences in UCVA, CA, SIT, NIKBUT, MIKTMH, IL-1β and TGF-β1 between the two groups before surgery (all P>0.05). The postoperative swelling time, congestion regression time and corneal epithelial healing time in combined group were significantly shorter than those in control group, and the postoperative recurrence rate was significantly lower than that in control group (all P<0.05). After surgery, the UCVA, SIT, NIKBUT and MIKTMH in the two groups were higher than those before surgery, and the absolute differences of UCVA, SIT, NIKBUT and MIKTMH before and after surgery in combined group were greater than those in control group (all P<0.05). The CA in both groups of patients was lower than that before surgery, and the absolute difference of CA before and after surgery was greater in combined group than that in control group (all P<0.05). After surgery, the level of IL-1β in tear in the two groups was reduced compared with that before surgery, and the absolute difference of IL-1β before and after surgery in combined group was lower than that in control group, and the level of TGF-β1 was enhanced compared to before surgery, and the absolute difference of TGF-β1 before and after surgery was higher in combined group than that in control group (all P<0.05). There was no statistical significance in the total incidence rate of postoperative complications between groups (P>0.05). The incidence rate of postoperative discomfort in combined group was lower compared to control group (P<0.05). Conclusion: LSCT combined with AMT is beneficial to the recovery of postoperative visual acuity, improvement of tear function and reduction of postoperative discomfort in patients with pterygium excision.

Key words： Autologous limbal stem cell transplantation Amniotic membrane transplantation Pterygium excision Visual acuity recovery status Tear function

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	HU Na
	LI Ting

Cite this article:

HU Na,LI Ting. Influences of Autologous Limbal Stem Cell Transplantation Combined with Amniotic Membrane Transplantation on Patients with Pterygium Excision[J]. HeBei Med, 2025, 31(8): 1354-1359.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.08.022 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I8/1354