ABCD<sup>2</sup>评分联合血清和肽素 Lp-PLA<sub>2</sub>水平预测短暂性脑缺血发作7d内缺血性脑卒中发作的价值

doi:10.3969/j.issn.1006-6233.2025.08.027

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Abstract Objective: To explore the application value of ABCD² score combined with serum copeptin and lipoprotein-associated phospholipase (Lp-PL) A₂ levels in predicting the prognosis of patients with transient ischemic attack (TIA) within 7 days. Methods: The clinical data of 114 patients with TIA were retrospectively analyzed from January 2020 to December 2023. According to the occurrence of ischemic stroke (CIS) after TIA, the patients were divided into CIS occurrence group (n=18) and CIS non-occurrence group (n=96). The general data of the two groups were collected. The ABCD² scoring system was used to evaluate all patients, and the levels of serum copeptin and Lp-PLA₂ were detected. Multivariate Logistic regression model was used to analyze the independent risk factors affecting the prognosis of patients with TIA. Receiver operating characteristic (ROC) curve and the maximum Youden index were adopted to analyze the predictive value of each factor on the prognosis of patients with TIA. Results: The ABCD² score, serum copeptin and Lp-PLA₂ levels in the CIS occurrence group were higher than those in the CIS non-occurrence group (P<0.05). Logistic regression analysis showed that ABCD² score, copeptin and Lp-PLA₂ were independent risk factors for TIA. ROC curve results showed that the area under the curve (AUC) of ABCD² score, serum copeptin and Lp-PLA₂ levels were 0.779 (0.702~0.855), 0.843 (0.780-0.906) and 0.760 (0.681~0.838), respectively. The cut-off values of each index were 4 points, 174.34mg/L and 16.49pmol/L, respectively. The area under the curve (AUC) of combined prediction was 0.925 (0.881~0.968), and the prediction efficiency was the highest. Conclusion: Clinically, it is necessary to take early warning measures for TIA patients with ABCD² score>4point, serum copeptin level>16.49pmol/L and serum Lp-PLA₂>174.34mg/L to prevent poor prognosis.

Key words： Transient ischemic attack ABCD² score Copeptin Lp-PLA₂ Prognosis

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.08.027 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I8/1382

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