卡前列素氨丁三醇联合缩宫素对剖宫产产后出血的疗效及对氧化应激凝血功能的影响

doi:10.3969/j.issn.1006-6233.2018.11.018

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Abstract Objective: To study the effect of carboprost tromethamine combined with oxytocin on postpartum hemorrhage after cesarean section and effects on, and oxidative stress and coagulation function. Methods: 130 patients of cesarean section who received therapy from December 2014 to December 2017 in our hospital were selected as research objects, according to random number table, those patients were divided into the observation group (n=65) and the control group (n=65), after the birth of the fetus, the control group was treated with oxytocin, while the observation group was combined with Carboprost Tromethamine. The postpartum hemorrhage, duration of uterine contraction, duration of uterine fundus, lochia duration, stress index, coagulation function and adverse reaction were compared between the two groups. Results: The bleeding volume of 2h and 24h in the observation group was significantly less than that of the control group, the postpartum hemorrhage rate in the observation group was 6.15% (4/65), which was also significantly lower than that in the control group 18.46% (12/65) (P<0.05); the observation group had longer uterine contraction, faster descending rate of uterine fundus, and shorter duration of lochia, compared with the control group, there were significant differences (P<0.05); at the end of operation and at after operation 24h, the malondialdehyde (MDA) in the observation group was significantly lower than that of the control group, and superoxide dismutase (SOD), glutathione peroxidase (GSH-px) and catalase (CAT) were significantly higher than that of the control group(P<0.05); at the end of operation and at after operation 24h, the fibrinogen (FBI), D- two polymer (D-D) in the observation group was significantly lower than that of the control group (P<0.05); there were no significant differences in facial flushing, nausea, vomiting, headache and chest tightness between the two groups(P>0.05). Conclusion: Carboprost tromethamine combined with oxytocin is well for prevention of postpartum hemorrhage in caesarean section, it's helpful for relieving perioperative stress reaction and improve blood coagulation function, and has high safety, it's worthy of application and promotion.

Key words： Cesarean section Postpartum hemorrhage Carboprost tromethamine Oxytocin

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	HAN Huihui
	FENG Chong
	HEI Jiangrong

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HAN Huihui,FENG Chong,HEI Jiangrong. Effect of Carboprost Tromethamine combined with Oxytocin on Postpartum Hemorrhage after Cesarean Section and its Influence on Oxidative Stress and Coagulation Function[J]. HeBei Med, 2018, 24(11): 1833-1837.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.11.018 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I11/1833

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