2型糖尿病患者并发左心室舒张功能减退的危险因素分析

doi:10.3969/j.issn.1006-6233.2018.12.016

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Abstract Objective: Although diabetes mellitus is an indepent risk of heart failure with preserved ejection fraction, the underlying mechanisms leading to c remain poorly understood. The study was aimed to access the risk factors for LVDD in patients with type 2 diabetes mellitus. Methods: 101 asymptomatic patients with type 2 diabetes mellitus without overt heart disease were enrolled in this study. Patients with New York Heart Association class>1, ejection fraction<50%, history of coronary artery disease, severe valvulopathy, chronic atrial fibrillation, or creatinine clearance<30 mL/min, as well as those receiving insulin treatment, were excluded. Among all 101 patients, 43 patients were found combined with heart failure with preserved ejection fraction. Left ventricular diastolic function was estimated as the ratio of early diastolic velocity (E) from transmitral inflow to early diastolic velocity(e') of tissue Doppler at mitral annulus(E/e'). Total patients were divided into two groups, normal and heart failure with preserved ejection fraction. Parameters of glycemic control, plasma insulin concentration, lipid profile, treatment with antidiabetic drugs, and other clinical characteristics were evaluated, and their association with heart failure with preserved ejection fraction determined. Results:Results showed that sex, duration of diabetes, systolic blood pressure, pulse pressure, fasting insulin concentration, and sulfonylurea use have significant differences between two groups .Logistic analysis showed that Sex (female), duration of diabetes, hypertension, hyperinsulinemia and sulfonylurea use maybe risk factors in the development of LVDD in patients with type 2 diabetes mellitus . Conclusion: Sex (female), duration of diabetes, hypertension, hyperinsulinemia and sulfonylurea use maybe risk factors in the development of LVDD in patients with type 2 diabetes mellitus.

Key words： Type 2 diabetes mellitus LVDD Sulfonylurea Duration of diabetes.

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	XU Jinmei
	LI Bo

Cite this article:

XU Jinmei,LI Bo. The risk factors of type 2 diabetes mellitus combined with left wentricular diastolic dysfunction[J]. HeBei Med, 2018, 24(12): 2000-2003.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2018.12.016 OR http://www.hbyxzzs.cn/EN/Y2018/V24/I12/2000

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