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| Effect of Guizhi Fuling Pill Combined with Albendazole on Serum VEGF and Flk-1 and Inflammatory Factors Levels of Patients with Endometriosis |
| LEI Xia, WANG Yuan, SHI Xiaoyan, et al |
| The Affiliated Hospital of Yan'an University, Shaanxi Yanan 716000, China |
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Abstract Objective: To explore the clinical efficacy of Guizhi fuling capsules combined with albendazole in the treatment of endometriosis (EMT) and effects on the serum levels of vascular endothelial growth factor (VEGF), fetal liver kinase (Flk-1) and inflammatory factors. Methods: 116 patients with EMT admitted in our hospital from February 2015 to December 2016 were selected and randomly divided into two groups. The patients in control group were treated with pantoprazole while the patients in the observation group were treated with Guizhi Fuling pill and albendazole. The clinical efficacy, the levels of serum VEGF, Flk-1, inflammatory factors before and after treatment and incidence of adverse reactions were compared between two groups. Results: After treatment, the total effective rate of observation group was 93.1%, which was significantly higher than that of the control group (P<0.05). Compared with before treatment, the levels of serum VEGF, Flk-1 IL-6, IL-8 and CRP of two groups after treatment were significantly lower than before (P<0.01), and the observation group were lower than those of the control group (P<0.01). There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: Guizhi Fuling pill combined with albendazole can effectively enhance the clinical efficacy with high safety in the treatment of EMT. It may be related to the decrease of serum VEGF, Flk-1 and inflammatory factors levels.
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2018, Vol. 24 
