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| Effects of Auer Bodies on the Prognosis of Newly Diagnosed Non-M3 Acute Myeloid Leukemia Patients |
| JIANG Juan, JIANG Yuan, SHEN Hong |
| Chizhou People's Hospital, Anhui Chizhou 247100, China |
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Abstract Objective: To analyze the effect of Auer bodies on the prognosis of newly diagnosed non-M3 acute myeloid leukemia (AML) patients.Methods: From January 2017 to January 2022, 124 newly diagnosed non-M3 AML patients in Chizhou People's Hospital were retrospectively selected as the research subjects, and the patients were divided into Auer body positive group and Auer body negative group according to the presence or absence of Auer bodies in bone marrow blast cells. In the negative group, the clinical characteristics such as age, gender, disease risk classification, laboratory indicators, and success rate of induction of remission were recorded. The clinical outcome and prognosis of the patients were followed up, and the Kaplan-Meier survival curve was plotted to compare the overall survival (OS) of the two groups of patients. Results: Among the 124 non-M3 AML patients, 54 were Auer body positive and 70 were Auer body negative. There was no difference between the two groups in age, sex, medical history, fever, bleeding, pain, anemia, and disease risk classification. There was statistical significance (P>0.05), and there was a statistically significant difference in the proportion of combined cardiovascular disease and digestive system disease (P<0.05); there was no significant difference in laboratory indicators WBC, PLT, Hb, and LDH between the two groups (P>0.05). There was no significant difference in the proportion of fusion genes (P>0.05). There was no significant difference in the complete remission rate and recurrence rate between the two groups, P>0.05, but the mortality rate of the Auer body positive group was lower than that of the Auer body negative group, and the difference was statistically significant (P<0.05); Kaplan-Meier survival curves showed no statistically significant difference in progression-free survival (DFS) between the two groups (P>0.05), but the OS of the Auer body positive group was higher than that of the Auer body negative group, and the difference was statistically significant (P<0.05). Conclusion: Auer bodies are closely related to the prognosis of newly diagnosed non-M3 AML patients. Patients with positive Auer bodies are less likely to have cardiovascular disease, are more likely to have digestive system symptoms, and have a lower mortality rate. The overall survival and prognosis are better than those with negative Auer bodies. Attention should be paid.
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[1] 杜晓亮,温凯丽,孟月,等.儿童急性髓系白血病流行病学回顾性分析[J].中国病案,2021,22(8):81-84.
[2] 张瑞东,王林娅,郑胡镛.世界卫生组织2016急性白血病分型解读[J].中华儿科杂志,2017,55(1):15-18.
[3] 马金龙,周安琪,顾思雨,等.急性髓系白血病伴骨髓增生异常相关改变的临床与遗传学特征研究[J].中国实验血液学杂志,2021,29(6):1757-1762.
[4] 米瑞华,郭珍,刘雯,等.伴TP53基因异常的急性白血病患者的临床特征和疗效分析[J].中华医学遗传学杂志,2021,38(10):955-960.
[5] 陈霞,阮敏,郭晔,等.世界卫生组织2016分型标准对儿童急性红白血病再评价[J].中华实用儿科临床杂志,2022,37(5):338-342.
[6] Huang huijun,Qin tiejun,Xu zefeng,et al.Mutational features of myelodysplastic syndromes with auer rods reveal them are more akin to acute myeloid leukemia[J].British Journal of Haematology,2020,188(5):796-800.
[7] 赵理平,陈兴,胡玲玲,等.1例伴45,X,-X,t(8;21)(q22;q22),del(9)(q22)M2型急性髓系白血病患儿的早期诊断[J].广东医学,2021,42(6):731-734.
[8] 陈枫煜,裴强,王启,等.以骨髓增殖性肿瘤为首发表现的T淋巴母细胞淋巴瘤合并急性髓系白血病1例并文献复习[J].重庆医学,2020,49(14):2373-2376,2379.
[9] Virk H,Khaire N,Sreedharanunni S,et al.Significance of dysplastic neutrophils with multiple auer rods in post-therapy acute promyelocytic leukemia[J].Indian Hematol Blood Transfus,2022,38(1):199-201. |
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2022, Vol. 28 
