|
|
|
| Clinicopathological Features Immunohistochemical Features and Prognosis of Clear Cell Renal Cell Carcinoma and Papillary Renal Cell Carcinoma |
| LI Hui, et al |
| Nanping First Hospital, Fujian Medical University, Fujian Nanping 353000, China |
|
|
|
|
Abstract Objective: To analyze the clinicopathological features, immunohistochemical features and prognosis of clear cell renal cell carcinoma (CCRCC) and papillary renal cell carcinoma (PRCC).Methods: The clinical data of 80 patients with renal cell carcinoma in the hospital from April 2021 to April 2023 were retrospectively analyzed. According to the pathological results, the patients were divided into CCRCC group (n=50) and PRCC group (n=30). The basic data, clinicopathological features and immunohistochemical features were compared between the two groups. All patients received surgical treatment and were followed up after discharge. The survival status at 1 year after surgery was counted and compared.Results: The hematuria ratio in CCRCC group was lower than that in PRCC group (P<0.05). There were no statistical differences in tumor diameter, T staging, N staging, M staging, renal envelope invasion and Fuhrman grading between CCRCC group and PRCC group (P>0.05). The positive rate of CD10 in CCRCC group was higher than that in PRCC group (P<0.05) while the positive rate of CK7 was lower than that in PRCC group (P<0.05), but the positive rates of PAX-8, TFE-3 and Vimentin revealed no statistical differences between CCRCC group and PRCC group (P>0.05). There was no statistical significance in survival status at 1 year after surgery in CCRCC group compared to PRCC group (P>0.05).Conclusion: There are differences in hematuria and immunohistochemical CD10 and CK7 positive expressions between CCRCC patients and PRCC patients, and the short-term prognosis is similar.
|
|
|
|
|
|
[1] Manzi M,Martin Palazzo,Maria Elena Knott,et al.Coupled mass-spectrometry-based lipidomics machine learning approach for early detection of clear cell renal cell carcinoma[J].Journal of Proteome Research,2020,20(1):841-857.
[2] A S Z,A K S,A R Z,et al.Cancer incidence and mortality in China,2015[J].Journal of the National Cancer Center,2021,1(1):2-11.
[3] Shimamura Y,Ishikawa S,Takizawa H.Unusual etiology of persistent fever after urinary tract infection:papillary renal cell carcinoma[J].Journal of General and Family Medicine,2020,21(5):193-194.
[4] Gessner K H,Kim W Y,Zambrano I A.Genomic meta-analysis of clear-cell renal cell carcinoma (ccRCC):aggregating tumors to resolve the complexity of ccRCC[J].European urology,2022,81(4):362-363.
[5] Liu S,Li S,Wang Y,et al.Prognostic value of infiltrating immune cells in clear cell renal cell carcinoma (ccRCC)[J].Journal of Cellular Biochemistry,2020,121(3):2571-2581.
[6] 王家武,姜庆.乳头状肾细胞癌预后预测模型的构建与验证:一项基于SEER数据库的回顾性研究[J].重庆医科大学学报,2023,48(8):986-994.
[7] 洪保安,侯惠民,陈凌霄,等.乳头状肾细胞癌的临床病理特征及预后分析[J].中华泌尿外科杂志,2020,41(12):896-900.
[8] Pol J A A,George L,Brandt P A,et al.Etiologic heterogeneity of clear‐cell and papillary renal cell carcinoma in the netherlands cohort Study[J].International Journal of Cancer,2021,148(1):67-76.
[9] 兰秋霞,张茜,肖华亮,等.肾脏黏液样小管状和梭形细胞癌的临床病理观察[J].重庆医学,2023,52(18):2825-2829.
[10] 顾宇峰,达建萍,周昱霖,等.透明细胞乳头状肾细胞癌临床病理特征与预后分析[J].现代泌尿外科杂志,2023,28(3):186-191. |
|
|
|
2024, Vol. 30 
