生物陶瓷充填材料和AH-plus糊剂对成人慢性根尖周炎根管治疗疗效及血清骨保护素RANKL的影响

doi:10.3969/j.issn.1006-6233.2025.01.016

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Abstract Objective: To investigate the influence of root repair material SP (iRoot SP) and AH-plus paste on the efficacy of root canal therapy and serum osteoprotegerin (OPG) and receptor activator of nuclear factor-κB ligand (RANKL) levels in adult patients with chronic apical periodontitis (CAP). Methods: A total of 135adult CAP patients who received root canal therapy in our hospital from January 2021 to December 2023 were selected as the study objects. They were randomly divided into the iRoot SP group (root SP root canal occluders as fillers for root canal therapy, n=68) and AH-plus group (AH-plus paste as a filling material for root canal therapy, n=67) by computer random number method. The filling status immediately after the treatment, pain grading at 7 days of treatment (T1), efficacy at T1, 3 months of treatment (T2) and 6 months of treatment (T3), old-periapical index (O-PAI), and serum OPG, RANKL and RANKL/OPG before treatment (T0) and at T1, T2 and T3 were compared between the iRoot SP group and the AH-plus group. Results: Compared with the AH-plus group, the appropriate filling rate in the iRoot SP group was significantly higher (98.53% vs.89.55%) (P<0.05). The decrease in the pain rate was significantly greater in the iRoot SP group than that of theAH-plus group (P<0.05). The effective rate at T1 (98.53% vs. 89.55%), T2 (95.59% vs. 85.07%) and T3 (91.18% vs. 79.10%) in the iRoot SP group was significantly higher in the iRoot SP group than the AH-plus group (P<0.05). There were significant differences in O-PAI, OPG, RANKL and RANKL/OPG from the aspects of intragroup effect, time-point effect and interaction effect (P<0.05), and the decreases in the O-PAI, RANKL and RANKL/OPG, and the increase in serum OPG were significantly greater in the iRoot SP group than those of the AH-plus group (P<0.05). Conclusion: Compared with AH-plus paste, iRoot SP as a filling material for root canal therapy of adult CAP is more effective, and the latter one can more significantly relieve the pain grading, serum RANKL expression and RANKL/OPG value, enhance the appropriate filling rate and serum OPG, and optimize the periodontal lesions.

Key words： Root repair material SP AH-plus paste Chronic apical periodontitis Osteoprotegerin Receptor activator of nuclear factor-κB ligand

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	CHEN Zhenzhen
	LIU Gang
	ZHU Kunkun

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CHEN Zhenzhen,LIU Gang,ZHU Kunkun. Influence of Root Repair Material SP and AH-plus Paste on the Efficacy of Root Canal therapy and Serum Osteoprotegerin and RANKL Levels in Adult Patients with Chronic Apical Periodontitis[J]. HeBei Med, 2025, 31(1): 91-96.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.01.016 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I1/91

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