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| Correlation and Predictive Value of sTREM-1 and Ghrelin/Obestatin with Postoperative Pulmonary Infection in Gastric Cancer |
| LIU Shenfang, MU Xiaoyan, XU Xiaoping, et al |
| Rehabilitation University Qingdao Central Hospital / Qingdao Central Hospital, Shandong Qingdao 266000, China |
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Abstract Objective: To analyze the correlation between soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), Ghrelin/Obestatin levels and postoperative pulmonary infection in gastric cancer, and evaluate their predictive value for postoperative pulmonary infection in gastric cancer. Methods: A total of 148 gastric cancer patients who underwent surgery at our hospital between June 2021 and June 2024 were enrolled. The serum levels of sTREM-1 and Ghrelin/Obestatin were measured on the day after surgery. The patients were followed up for 1 month postoperatively and divided into an infection group (n=65) and a non-infection group (n=83) based on the occurrence of pulmonary infection. The predictive value of sTREM-1 and Ghrelin/Obestatin levels for postoperative pulmonary infection was evaluated using receiver operating characteristic (ROC) curves. Results: The sTREM-1 level in the infection group was higher than that in the non-infection group, while the Ghrelin/Obestatin level in the infection group was lower than that in the non-infection group (P<0.05). The ROC curve showed that the area under the curve (AUC) for sTREM-1 and Ghrelin/Obestatin levels in predicting postoperative pulmonary infection in gastric cancer was 0.773 and 0.761, respectively, with sensitivity of 64.62% and 66.15%, and specificity of 84.34% and 77.11%, respectively. The AUC for combined prediction was 0.963, with sensitivity of 92.31% and specificity of 90.36%. The combined prediction performance was superior to that of individual markers (P<0.05). Conclusion: sTREM-1 and Ghrelin/Obestatin levels are closely associated with postoperative pulmonary infection in gastric cancer. Early measurement of these levels postoperatively may provide valuable predictive information for postoperative pulmonary infection in gastric cancer.
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2025, Vol. 31 
