不同胎龄早产儿振幅整合脑电图变化及与脑发育的关系

doi:10.3969/j.issn.1006-6233.2025.06.14

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Abstract Objective: To explore the relationship between changes of amplitude-integrated electroencephalogram (aEEG) and brain development in premature infants at different gestational ages. Methods: A total of 103 premature infants admitted to the hospital from January 2023 to April 2024 were selected as the research subjects. They were grouped according to gestational age. The changes of aEEG were analyzed. All subjects underwent multimodal magnetic resonance imaging (MRI) examination, and diffusion tensor imaging (DTI) was used to quantitatively evaluate their brain development. Spearman method was used to analyze the relationship between aEEG changes and brain development in premature infants at different gestational ages. Results: As gestational age increased, the positive rate of continuity (Co) increased. There were statistically significant differences in Co positive rate of aEEG among premature infants of different gestational ages (P<0.05). As gestational age increased, the positive rate of sleep-wakefulness cycle (SWC) increased. There were statistically significant differences in SWC positive rate of aEEG among premature infants of different gestational ages (P<0.05). As gestational age increased, lower-bound (LB) amplitude increased. There were statistically significant differences in LB of aEEG < 3μV and aEEG >5μV among premature infants of different gestational ages (P<0.05). As the gestational age increased, bandwidth (B) decreased, and there were statistically significant differences in B of aEEG among premature infants of different gestational ages (P<0.05). There were statistically significant differences in fractional anisotropy (FA) values of frontal white matter, parietal white matter, splenium of the corpus callosum, and cerebral peduncle among premature infants at different gestational ages (P<0.05). Spearman correlation analysis results showed that LB was negatively correlated with FA values of the splenium of the corpus callosum and cerebral peduncle. B was positively correlated with FA value of parietal white matter, and negatively correlated with FA value of cerebral peduncle (P<0.05). Conclusion: With the increase of gestational age, aEEG becomes mature, which mainly manifests as increases in Co and SWC positive rates, increase in LB and decrease in B. Closely related to brain development in premature infants.

Key words： Premature infant Amplitude-integrated electroencephalogram Gestational age Brain development

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.06.14 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I6/954

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