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| Correlation between TyG Index and Osteoporosis in Men over 50 Years of Age and Postmenopausal Women with Type 2 Diabetes |
| HE Jianqiu, ZHANG Rui, LIU Xiaoyan, et al |
| The Affiliated Hospital of Chengde Medical University / Hebei Key Laboratory of Panvascular Diseases, Hebei Chengde 067000, China |
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Abstract Objective: To explore the correlation between indicators related to glucose and lipid metabolism and osteoporosis in patients with type 2 diabetes mellitus (T2DM). Methods: A total of 404 T2DM patients, including 181 males over 50 years old and 223 postmenopausal females, were selected. Dual-energy X-ray absorptiometry (DXA) was used to detect bone mineral density (BMD) of the lumbar spine (L1~L4), femoral neck, and total hip. According to the T-score, patients were divided into three subgroups: normal group (185 cases), osteopenia group (131 cases), and osteoporosis group (88 cases). Indicators related to glucose and lipid metabolism were measured, and the TyG index was calculated to compare differences among groups. Results: In male patients, TyG index in the normal group was higher than that in the osteopenia and osteoporosis group (F=3.251, P=0.041); and in female patients, TYG index in the normal group was higher than that in the osteopenia and osteoporosis group (F=5.591, P=0.004), the uric acid in normal group was higher than that in the osteopenia and osteoporosis group (F=17.203, P<0.001). Logistic regression analysis showed that the TyG index was a protective factor for osteoporosis in male T2DM patients over 50 years old (OR=0.405, P=0.049). TyG index (OR=0.834,P<0.001) and uric acid (OR=0.991, P<0.001) were the protective factors for osteoporosis in postmenopausal women with T2DM. Conclusion: TyG index is a protective factor for osteoporosis in male T2DM patients over 50 years old and in postmenopausal women, and uric acid is a protective factor for osteoporosis in postmenopausal women with T2DM.
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2025, Vol. 31 
