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| Effects of Ethacridine combined with Dinoprofen in treatment of Maternal Cervix and its Influcences on Bishop score, PGE2α, ET-1 level and Pregnancy outcome |
| MENG Qingtang, YE Qing, WU Xiujuan |
| Tai'an Maternal and Child Health-Care Hospital, Shandong Tai'an 271000, China |
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Abstract Objective: To study the effects of ethacridine combined with dinoprofenone in treatment of maternal cervix and its effects on Bishop score, PGE2α, ET-1 level and pregnancy outcome. Methods: From April 2015 to March 2016, 86 pregnant women admitted in our hospital, randomly divided into observation group and control group, 43 cases per group. The control group was treated with dinoprofen, and the observation group was treated ethacridine on the basis of control group. The two groups of patients with cervical ripening, Bishop score, PGE2α, ET-1 levels, induction of labor were compared. Results: After treatment, the cervical Bishop score of the observation group was significantly higher than that of the control group(9.21±0.96 vs5.98±0.62 P<0.05), and the cervical ripening within 3 days was significantly better than that of the control group [93.02%(40/43) vs 72.09%(31/43)P<0.05]. The levels of PGE2α and ET-1 in the observation group were significantly higher than those in the control group [(8.78±0.82 vs 6.97±0.68 P<0.05), (3.26±0.38 vs 2.96±0.29 P<0.05)]. The rate of fetal distress and breaking rate in the observation group was significantly lower than that in the control group [4.65%(2/43)vs 25.58% (11/43)、6.98%(3/43)vs 27.91%(12/43)](P<0.05). There was no significant difference in the adverse reaction rate between the observation group and the control group [2.32%(1/43)vs 4.65%(2/43)](P>0.05). Conclusion: Ethacridine combined with dinoprofen can effectively promote maternal cervical maturation and improve the level of PGE2α and ET-1, which can effectively improve the outcome of pregnancy.
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2018, Vol. 24 
