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| The Study Correlation between Liver Stiffness and Pathological Staging of Liver Biopsy in Patients with Chronic Hepatitis B by Fibroscan |
| CAO Faming, ZHANG Zhaoru, WANG Xiang |
| Chaohu Hospital Affiliated to Medical University; Anhui Chaohu 238000, China |
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Abstract Objective: To observe the correlation between liver stiffness measured by transient elastography (Fibroscan) and liver biopsy pathological stage of patients with chronic hepatitis B. Methods: 196 cases of patients with chronic hepatitis B who were admitted to the hospital from January 2016 to January 2018 were selected as the subjects. All patients underwent liver biopsy to determine the stage of liver fibrosis, and Fibroscan was used for liver stiffness measurement (LSM). The correlation of LSM with liver fibrosis was analyzed. Results: The sensitivity, specificity, accuracy and Kappa value of Fibroscan in detecting LSM stage S0 were 92.31% (12/13), 100.00% (183/183), 99.49% (195/196) and 0.96, respectively. For S1, the sensitivity, specificity, accuracy and Kappa value were 100.00%(54/54), 97.18%(138/142), 97.96%(192/196)and 0.95, respectively. Those for S2 were 97.18%(69/71), 99.20%(124/125), 98.47%(193/196)and 0.97, respectively, for S3 were 93.33% (42/45), 100.00% (151/151), 98.47% (193/196) and 0.96, respectively, and for S4 were 92.31%(12/13), 98.91%(181/183), 98.48%(193/196)and 0.88, respectively. Levels of ALT, AST, Knodell score and LSM were significantly lower in the mild fibrosis group than in the moderate and severe fibrosis group (P < 0.05). The LSM measured by Fibroscan was an independent risk factor for liver biopsy pathological stage (P < 0.05), and it was positively correlated with Knodell score and liver biopsy pathological stage (P < 0.05). Conclusion: Fibroscan can be used as a reference for evaluating the stage of liver fibrosis. Instead of partial liver biopsy, it is of great value for early diagnosis of liver cirrhosis.
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2018, Vol. 24 
