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| Effects of High-dose Vitamin E Plus Ultra-heparin on Oxidative Stress and Microinflammatory state in Children with Henoch-schonlein Purpura |
| ZHU Li |
| Fushun Central Hospital, Liaoning Fushun 113006, China |
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Abstract Objective: To study the effects of high dose of vitamin E plus ultra - micro - heparin on oxidative stress and microinflammatory state in children with henoch-schonlein purpura. Methods: 114 children with Henoch-Schonlein purpura were enrolled in this study from August 2012 to January 2016. All children were divided into control group (n = 57 cases) and study group (n = 57 cases) according to the digital table method. The control group of children with conventional treatment of allergic purpura method, the study group of children in the control group based on the use of large doses of vitamin E and ultra-micro heparin. Results: After treatment, all the indexes of the study group decreased significantly (P <0.05), and there was significant difference between the two groups (P <0.05). All patients had no obvious abnormality of coagulation time, bleeding time and platelet count before and after treatment, and all children treated with heparin had no severe allergic reaction and side effects. All the children's blood lipids, Hb, ALB, etc. were no significant abnormalities, all large doses of vitamin E in children with no significant thrombosis, bleeding and other side effects. The total effective rate in the control group was 78.9%, significantly lower than the total effective rate of the study group was 96.5% (P <0.05). In the control group, 14 out of 57 patients had nephritis and the incidence of HSPN was 24.6%. In the study group, 4 patients had nephritis, and the incidence of HSPN was 7.0%. The incidence of HSPN in the control group was significantly higher than that in the study group (χ2 = 5.377, P <0.05). Conclusion: The synergistic effect of ultra-micro-heparin plus high dose of vitamin E on different pathogenesis of HSP can significantly reduce the incidence of HSP nephropathy and improve the micro-inflammatory state and oxidative stress state of HSP.
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2018, Vol. 24 
