|
|
|
| Association of Placental Growth Factor Levels with Fetal Cardiac Monitoring and Intrauterine Fetal Growth Restriction in Pregnant Women with Pre-Eclampsia |
| LIN Wenyi, WANG Qing, WENG Meijuan, et al |
| General Hospital of the Southern Theater Command of the Chinese People's Liberation Army, Guangdong Guangzhou 510010, China |
|
|
|
|
Abstract Objective: To analyze the association between placental growth factor level and fetal heart rate monitoring and fetal intrauterine growth restriction in pregnant women with preeclampsia. Methods: A total of 131 pregnant women with preeclampsia diagnosed in the hospital were selected from June 2020 to June 2023 as the research subjects. According to whether they were complicated with fetal intrauterine growth restriction, they were divided into preeclampsia without fetal growth restriction group (n=70) and preeclampsia with fetal growth restriction group (n=61). All study subjects were tested for placental growth factor level, and fetal heart rate monitoring was performed at more than 28 weeks of gestation. The receiver operating characteristic (ROC) curve was used to analyze the evaluated value of the placental growth factor on fetal intrauterine growth restriction in pregnant women with preeclampsia.Results: The level of placental growth factor in preeclampsia with fetal growth restriction group was lower than that in preeclampsia without fetal growth restriction group (P<0.05). The abnormal rate of fetal heart rate monitoring was higher in preeclampsia with fetal growth restriction group than that in preeclampsia without fetal growth restriction group (P<0.05). ROC curve analysis showed that the area under the curve (AUC), sensitivity, and specificity of placental growth factor in evaluating fetal intrauterine growth restriction in pregnant women with preeclampsia were 0.797, 91.80%, and 57.14%.Conclusion: The level of placental growth factor is closely related to fetal heart rate monitoring and fetal intrauterine growth restriction in pregnant women with preeclampsia. Placental growth factor detection and fetal heart rate monitoring can provide a reference for the evaluation of fetal intrauterine growth restriction in pregnant women with preeclampsia.
|
|
|
|
|
|
[1] Mendoza M,Bonacina E,Garcia-Manau P,et al.Aspirin discontinuation at 24 to 28 weeks' gestation in pregnancies at high risk of preterm preeclampsia:a randomized cinical trial[J].JAMA,2023,329(7):542-550.
[2] Huai J,Lin L,Juan J,et al.Preventive effect of aspirin on preeclampsia in high-risk pregnant women with stage 1 hypertension[J].Clin Hypertens (Greenwich),2021,23(5):1060-1067.
[3] Hurrell A,Beardmore-Gray A,Duhig K,et al.Placental growth factor in suspected preterm pre-eclampsia:a review of the evidence and practicalities of implementation[J].BJOG,2020,127(13):1590-1597.
[4] 杨梅琳.胎盘生长因子与妊娠不良结局的研究进展[J].福建医科大学学报,2023,57(1):74-78.
[5] Hauspurg A,Jeyabalan A.Postpartum preeclampsia or eclampsia:defining its place and management among the hypertensive disorders of pregnancy[J].Am Obstet Gynecol,2022,226(2):1211-1221.
[6] Joo EH,Kim YR,Kim N,et al.Effect of endogenic and exogenic oxidative stress triggers on adverse pregnancy outcomes:preeclampsia,fetal growth restriction,gestational diabetes mellitus and preterm birth[J].Int Mol Sci,2021,22(18):10122.
[7] 朱念念,赵敏,夏闪.妊娠期高血压疾病患者孕晚期血清PLGF、VEGF水平与胎儿生长受限的关系[J].山东医药,2022,62(31):31-34.
[8] 陈嵘,林小红,麦彩园,等.母血和脐血中HIF-1α、VEGF-A、PlGF的表达和胎儿生长受限的相关性分析[J].中国妇产科临床杂志,2021,22(3):287-288.
[9] 万雪华,马爱娟.血清胎盘生长因子水平与子痫前期胎儿生长受限的关联性[J].分子诊断与治疗杂志,2020,12(9):1192-1194,1199. |
|
|
|
2024, Vol. 30 
