尿素氮肌酐和胱抑素c对足月窒息新生儿发生急性肾损伤的预测价值分析

doi:10.3969/j.issn.1006-6233.2024.09.018

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Abstract Objective: To analyze the predictive value of blood urea nitrogen (BUN), serum creatinine (SCr), and cystatin C (CysC) for acute kidney injury (AKI) in asphyxiated full-term neonates.Methods: The clinical data of 85 asphyxiated full-term neonates born in the hospital from January 2020 to June 2023 were collected retrospectively. According to the presence or absence of AKI, neonates selected were divided into the AKI group (n=30) and the non-AKI group (n=55). The clinical data, BUN, SCr, and CysC of the two groups were compared. Multivariate logistic regression analysis was performed to identify the risk factors for AKI in asphyxiated full-term neonates. The receiver operating characteristic (ROC) curves were used to analyze the predictive value of BUN, SCr, and CysC for AKI in asphyxiated full-term neonates.Results: There was no statistically significant difference in gender, gestational age, birth weight, delivery mode, or number of births between the two groups (P>0.05). The proportion of severe asphyxia and the levels of BUN, SCr, and CysC in the AKI group were higher than those in the non-AKI group (P<0.05). Logistic regression analysis found that severe asphyxia and abnormally elevated levels of BUN, SCr and CysC were independent factors in predicting the development of AKI in term neonates with asphyxia (P<0.05). ROC curves indicated that BUN, SCr, and CysC had certain predictive values for AKI in asphyxiated full-term neonates. Among them, the area under the curve (AUC) and sensitivity of CysC were higher than those of BUN and SCr (P<0.05).Conclusion: BUN, SCr, and CysC level tests are of relevance in guiding the development of AKI in full-term asphyxiated neonates, and serum CysC has the best guiding value.

Key words： Full-term neonate Neonatal asphyxia Acute kidney injury Urea nitrogen Creatinine Cystatin C

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.09.018 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I9/1509

[1] Turgut S,Tuba U S,Ahmet Z,et al.Volumetric apparent diffusion coefficient histogram analysis in term neonatal asphyxia treated with hypothermia[J].British Journal of Radiology,2024,97(18):1302-1310.
[2] Hemmingsen D,Moster D,Klingenberg E C.Hearing impairment after asphyxia and neonatal encephalopathy:a Norwegian population-based study[J].European journal of pediatrics,2024,183(3):1163-1172.
[3] Veer M A A V D,Haan T R D,Franken L G W,et al.Predictive performance of a gentamicin pharmacokinetic model in term neonates with perinatal asphyxia undergoing controlled therapeutic hypothermia[J].Therapeutic Drug Monitoring,2024,46(3):376-383.
[4] 喻晓露,贾舒雯.新生儿急性肾损伤的临床特征调查及相关预后影响因素分析[J].中国中西医结合肾病杂志,2022,23(11):1008-1010.
[5] 滑瑞雪,邹陆曦,吴雨,等.基于血肌酐变化参考值的急性肾损伤诊断标准对慢性肾脏病患者急性肾损伤的诊断及慢性肾脏病进展,全因死亡风险的预测研究[J].临床肾脏病杂志,2022,22(12):999-1005.
[6] 挤压综合征急性肾损伤诊治协助组.挤压综合征急性肾损伤诊治的专家共识[J].中华医学杂志,2013,93(17):1297-1300.
[7] 中华医学会围产医学分会新生儿复苏学组.新生儿窒息诊断的专家共识[J].中华围产医学杂志,2016,19(1):3-6.
[8] Ramsie M,Cheung P Y,Lee T F,et al.Comparison of various vasopressin doses to epinephrine during cardiopulmonary resuscitation in asphyxiated neonatal piglets[J].Pediatric Research,2023,95(5):1265-1272.
[9] Grossmann K R,Vishnevskaya L,Ruiz S D,et al.Kidney outcomes in early adolescence following perinatal asphyxia and hypothermia-treated hypoxic-ischaemic encephalopathy[J].Pediatric nephrology (Berlin,Germany),2022,38(4):1205-1214.
[10] 蔡雅丽,张伟峰,康淑琴,等.尿肝型脂肪酸结合蛋白对新生儿窒息后急性肾损伤的临床价值[J].国际泌尿系统杂志,2021,41(6):1059-1062.
[11] Gallo D,Bijl-Marcus K A D,Alderliesten T,et al.Early Acute Kidney Injury in Preterm and Term Neonates:Incidence,Outcome,and Associated Clinical Features[J].Neonatology,2021,118(2):1-6.
[12] 陈欣,高天巍,李沂伟,等.血尿酸/血肌酐比值对重症急性胰腺炎患者急性肾损伤的预测分析[J].中国卫生检验杂志,2023,33(15):1872-1875.