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| Correlation between Serum Mir-647 Levels and In-Stent Restenosis after Bare Metal Stent Placement in Patients with Lower Limb Atherosclerotic Occlusive Disease |
| ZHANG Chao, ZHANG Xiaojing, YANG Xiaojun, et al |
| Linfen People's Hospital, Shanxi Linfen 041099, China |
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Abstract Objective: To explore and analyze the association between serum short non-coding RNA-647 (miR-647) level and in-stent restenosis (ISR) in patients with lower extremity arteriosclerosis obliterans (ASO) after bare metal stent implantation.Methods: Totally 182 patients with lower extremity ASO in the hospital were enrolled from September 2020 to September 2023. Serum miR-647 level after bare metal stent implantation was detected, and the correlation between its level change and ISR was analyzed.Results: Out of 182 ASO patients, 43 experienced ISR after metal bare stent implantation, with an incidence rate of 23.63%. The levels of miR-647, neutrophil to lymphocyte ratio (NLR), and C-reactive protein (CRP) in ISR patients were significantly higher than those in non-ISR patients, with statistical significance (P<0.05). Univariate analysis showed statistical differences in Fontaine staging, age, hypertension, and diabetes mellitus between ASO patients with postoperative ISR and patients without ISR (P<0.05). Person correlation analysis showed that miR-647 was positively correlated with NLR and CRP levels (r=0.351, 0.402, P<0.05). Logistic regression analysis showed that Fontaine staging, age, miR-647, NLR, CRP level, hypertension, and diabetes mellitus were risk factors for postoperative ISR in ASO patients (P<0.05). Concerning the ROC curve, the area under the curve (AUC), optimal cut-off value, sensitivity, and specificity of miR-647 expression level in evaluating postoperative ISR were 0.767 (95%CI:0.676-0.858), 0.980, 0.581 and 0.899 respectively.Conclusion: Serum miR-647 expression in patients with ASO after bare metal stent implantation is related to the occurrence of ISR, and has certain predictive and evaluated value on the occurrence of ISR.
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2024, Vol. 30 
