高频彩超联合血清LAG-3 FGFR-4对甲状腺癌的诊断价值

doi:10.3969/j.issn.1006-6233.2024.09.024

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Abstract Objective: To investigate the expression of serum lymphocyte activation gene 3 (LAG-3) and fibroblast growth factor receptor 4 (FGFR-4) in thyroid cancer (TC), and the diagnostic value of them combined with high-frequency ultrasound for TC.Methods: A total of 203 patients with thyroid lesions admitted to our hospital from December 2020 to December 2023 were enrolled as the study subjects. Based on the pathological examination results, they were separated into TC patients as the TC group (n=108) and benign thyroid lesions patients as the non-TC group (n=95). ELISA method was applied to determine the expression levels of serum LAG-3 and FGFR-4. ROC curve was plotted to analyze the diagnostic efficacy of serum LAG-3 and FGFR-4 for TC. Four grid table method was applied to analyze the diagnostic efficacy of high-frequency ultrasound combined with serum LAG-3 and FGFR-4 levels for TC.Results: Compared with undifferentiated thyroid carcinoma, the serum LAG-3 level of papillary, follicular, and medullary thyroid carcinoma was significantly increased, and the serum FGFR-4 level was significantly decreased (P<0.05). Compared with the non-TC group, the serum LAG-3 level in the TC group was reduced, and the serum FGFR-4 level was increased (P<0.05). The levels of PSV and RI in the TC group were higher than those in the non-TC group (P<0.05). The accuracy, sensitivity, and specificity of high-frequency ultrasound combined with serum LAG-3 and FGFR-4 in diagnosing TC were 86.70%, 96.30%, and 75.79%, respectively. Among them, the sensitivity of the three combined diagnoses was higher than that of high-frequency ultrasound, serum LAG-3, and FGFR-4 individual diagnoses (P<0.05).Conclusion: The serum LAG-3 level in TC patients is reduced, while the serum FGFR-4 level is increased. High-frequency ultrasound combined with serum LAG-3 and FGFR-4 has higher diagnostic efficacy for TC.

Key words： Lymphocyte activation gene-3 Fibroblast growth factor receptor 4 High frequency color ultrasound Thyroid cancer Diagnosis

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	ZHAO Xinyan
	WANG Jun

Cite this article:

ZHAO Xinyan,WANG Jun. Diagnostic Value of High-Frequency Ultrasound Combined with Serum LAG-3 and FGFR-4 in Thyroid Cancer[J]. HeBei Med, 2024, 30(9): 1539-1544.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.09.024 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I9/1539

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