布地奈德联合干扰素α2b雾化治疗在婴幼儿支气管肺炎治疗中的疗效与安全性评估

doi:10.3969/j.issn.1006-6233.2024.10.029

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Abstract Objective: To evaluate the efficacy and safety of budesonide combined with interferon α2b nebulization in the treatment of infantile bronchopneumonia. Methods: A total of 102 infants and young children with bronchopneumonia admitted to our hospital from 2021.09 to 2023.07 were enrolled. According to the random number table method, they were divided into the conventional group (conventional symptomatic treatment + budesonide atomization inhalation) and combined group (combined with interferon α2b atomization inhalation on the basis of the conventional group), with 51 cases in each group. The clinical efficacy, improvement time of symptoms (cough, wheezing, wheezing rale, three concave signs), blood gas indexes [oxygenation index, partial pressure of oxygen (PaO₂), partial pressure of carbon dioxide (PaCO₂)], T lymphocyte indicators (CD3⁺CD4⁺, CD3⁺CD8⁺, CD3^-CD19+) and peripheral blood inflammation indexes [Interleukin-6 (IL-6), tumor necrosis factor α (TNF-α), C-reactive protein (CRP)] before and after treatment were compared between the two groups, and the adverse drug reactions were compared. Results: The total effective rate of the combined group (98.40%) was higher than that of the conventional group (86.27%) ((P<0.05). The improvement time of symptoms in the combined group was shorter than that in the conventional group (P<0.05). Before treatment, there were no statistical differences in serum indexes between groups (P>0.05). After treatment, the oxygenation index and PaO₂ in the two groups were increased (P<0.05) while the PaCO₂ was decreased (P<0.05), and the differences before and after treatment in the combined group were higher (P<0.05). No statistical differences were shown in T lymphocyte indexes between groups before treatment (P>0.05). After treatment, CD3⁺CD4⁺and CD3⁺CD8⁺ in both groups of children were risen (P<0.05) while CD3^-CD19++ was declined (P<0.05), and the differences before and after treatment were higher in the combined group than those in the conventional group (P<0.05). Before treatment, there were no statistical differences in peripheral blood inflammation indexes between groups (P>0.05). After treatment, the peripheral blood inflammatory indexes (IL-6, TNF-α, CRP) in the two groups were significantly decreased (P<0.05), and the differences before and after treatment in the combined group were higher than those in the conventional group (P<0.05). There was no statistical significance in the total incidence rate of adverse drug reactions between the combined group (7.84%) and the conventional group (5.88%) (P>0.05). Conclusion: Budesonide combined with interferon α2 b atomization inhalation is beneficial to improve the clinical symptoms, lung function and immune inflammatory response of infants and young children with bronchopneumonia, and improve the efficacy, with high safety.

Key words： Bronchopneumonia Spastic cough Budesonide Interferon α2b Glucocorticoid

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.10.029 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I10/1739

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