精蛋白重组人胰岛素混合注射液40/60治疗老年2型糖尿病的疗效及对患者预后的影响

doi:10.3969/j.issn.1006-6233.2024.10.028

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Abstract Objective: To explore the efficacy of protamine recombinant human insulin mix 40/60 (referred to as Gansulin 40/60) in treating elderly patients with type 2 diabetes (T2DM) and its impact on prognosis. Methods: A total of 106 elderly T2DM patients admitted to Western Theater General Hospital between December 2022 and December 2023 were randomly divided into a control group (n=53) and a treatment group (n=53). The control group received standard dual antidiabetic therapy (metformin + dapagliflozin), while the treatment group was given Gansulin 40/60 subcutaneous injections. After 12 weeks, efficacy and safety were evaluated, and pre- and post-treatment glycemic indicators, body mass index (BMI), β-cell function, and serum levels of monocyte chemoattractant protein-1 (MCP-1), high-sensitivity C-reactive protein (hs-CRP), and interleukin-6 (IL-6) were measured. The prognosis of both groups was tracked for 6 months. Results: The overall effective rate in the treatment group was 90.57%, higher than that in the control group (71.70%) (P<0.05). After treatment, the treatment group showed lower fasting plasma glucose (FPG), 2-hour postprandial glucose (2hPG), glycosylated hemoglobin (HbA1c), homeostasis model assessment of insulin resistance (HOMA-IR), and serum MCP-1, hs-CRP, and IL-6 levels, and higher β-cell function index (HOMA-β) compared to the control group (P<0.05). The overall incidence of adverse reactions in the treatment group (3.77%) was not significantly different from that in the control group (7.55%) (P>0.05). There was no significant difference in the incidence of microvascular complications between the two groups over the 6-month follow-up period (P>0.05). Conclusion: Subcutaneous injection of Gansulin 40/60 in elderly T2DM patients is safe and effective, lowering blood glucose levels, promoting β-cell function recovery, and reducing inflammation, though it does not significantly improve short-term prognosis.

Key words： Type 2 diabetes mellitus Elderly Protamine recombinant human insulin mixed injection 40/60 (Ganshulin 40/60) Blood glucose Glycated hemoglobin Prognosis

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	Articles by authors
	XIAO Yao
	PAN Yinhong
	MA Lihong
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Cite this article:

XIAO Yao,PAN Yinhong,MA Lihong, et al. Efficacy of Protamine Recombinant Human Insulin Mix 40/60 in Treating Elderly Patients with Type 2 Diabetes and Its Impact on Prognosis[J]. HeBei Med, 2024, 30(10): 1733-1738.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2024.10.028 OR http://www.hbyxzzs.cn/EN/Y2024/V30/I10/1733

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