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| Relationship Between Inflammatory Factors and Ocular Surface Function in Patients with Xerophthalmia After Modified Parks Incision Strabismus Surgery |
| CHENG Jingqian, WANG Shuang, QIN Dong |
| The Third People's Hospital of Chengdu, Sichuan Chengdu 610014, China |
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Abstract Objective: To analyze the changes in serum inflammatory factors in patients with xerophthalmia after modified Parks incision strabismus surgery and to investigate their association with ocular surface function. Methods: A total of 122 patients with strabismus who underwent modified Parks incision surgery at our hospital from March 2021 to March 2024 were included in this study. The changes in inflammatory factors among patients with xerophthalmia after surgery were observed, and the relationship between these changes and ocular surface function was analyzed. Results: The incidence rate of xerophthalmia after modified Parks incision strabismus surgery was 21.31% (26/122). The serum levels of IL-6, MMP-2, TNF-α, and TLR4 in patients with xerophthalmia were significantly higher than those in patients without xerophthalmia (P<0.05). There was a statistically significant difference in OSDI scores between patients with and without xerophthalmia (P<0.05). Pearson correlation analysis indicated that IL-6, MMP-2, TNF-α, and TLR4 were positively correlated with the degree of ocular surface dysfunction, with statistically significant correlations (r=0.482, 0.510, 0.351, 0.333, P<0.05). Linear regression analysis showed that IL-6, MMP-2, TNF-α, and TLR4 were risk factors affecting ocular surface function (P<0.05). ROC curve analysis revealed that the AUCs of serum IL-6, MMP-2, TNF-α, and TLR4 in evaluating ocular surface dysfunction were 0.668, 0.752, 0.743, and 0.766, respectively. The combined AUC of IL-6+MMP-2+TNF-α+TLR4 was 0.873, with a sensitivity and specificity of 0.769 and 0.854, respectively, under the maximum Youden index. Conclusion: The serum levels of IL-6, MMP-2, TNF-α, and TLR4 in patients with xerophthalmia after modified Parks incision strabismus surgery are abnormally increased and are related to the degree of ocular surface dysfunction. These levels have a high evaluative value for ocular surface dysfunction.
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2025, Vol. 31 
