鼻咽癌组织中miR-140-3p AGT5表达变化及临床意义

doi:10.3969/j.issn.1006-6233.2025.02.021

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Abstract Objective: To investigate the correlation between the expression of microRNA140-3p (miR-140-3p) and autophagy related gene 5 (AGT5) with pathological parameters and prognosis of nasopharyngeal carcinoma patients. Methods: A total of 102 nasopharyngeal carcinoma patients were selected as the research subjects. The expression of miR-140-3p and AGT5 in nasopharyngeal carcinoma tissues and adjacent tissues was detected by fluorescent quantitative polymerase chain reaction (qPCR) technology. The correlation of the expression levels of miR-140-3p and AGT5 in cancer tissues and adjacent tissues with pathological parameters and prognosis of nasopharyngeal carcinoma patients was assessed. After 3-year follow-up, the prognosis of patients with different expressions of miR-140-3 p and AGT5 was compared. Cox regression analysis was employed to analyze the factors affecting patient prognosis. Results: The expression levels of miR-140-3p and AGT5 in nasopharyngeal carcinoma tissues were significantly lower than those in adjacent tissues (t=23.657, 27.625, P=0.000, 0.000). There was a significant positive correlation between miR-140-3p and AGT5 expression in nasopharyngeal carcinoma tissues (r=0.614, P=0.000). The expression levels of miR-140-3p and AGT5 were significantly higher in patients with high differentiation, tumor-node-metastasis (TNM) stages Ⅰ~Ⅱ, and no lymph node metastasis than those with medium low differentiation, TNM stages Ⅲ~Ⅳ, and lymph node metastasis (P<0.05). The 3-year overall survival rate was 75.49% (77/102) among those patients. The 3-year overall survival rates of patients with high expression of miR-140-3p (≥0.97 ,n=49) and AGT5 (≥1.46, n=48) were significantly higher than those with low expression of miR-140-3p (＜0.97, n=53) and AGT5 (＜1.46, n=54)(87.76% [43/49] vs 64.15% [34/53], 87.50% [42/48] vs 64.81% [35/54], Log-Rankc 2=7.667, 7.063, P=0.006, 0.008). Low differentiation, TNM stage II-IV, and lymph node metastasis were independent risk factors for prognosis of patients with nasopharyngeal cancer. High expressions of miR-140-3p and AGT5 were protective factors for prognosis in patients with NPC (P<0.05). Conclusion: The downregulation of miR-140-3p and AGT5 expression in nasopharyngeal carcinoma patients is closely related to the occurrence, development, and prognosis of nasopharyngeal carcinoma via participating in the progression of nasopharyngeal carcinoma.

Key words： Nasopharyngeal cancer Micro RNA140-3p Autophagy related genes 5 Pathological features Prognostic

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	HUANG Changqun
	YANG Xiaoyu
	HU Wei

Cite this article:

HUANG Changqun,YANG Xiaoyu,HU Wei. Expression Changes and Clinical Significance of miR-140-3p AGT5 in Nasopharyngeal Carcinoma Tissue[J]. HeBei Med, 2025, 31(2): 297-301.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.02.021 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I2/297

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