经尿道钬激光剜除术对非肌层浸润性膀胱癌术后尿路功能恢复生活质量及预后的影响

doi:10.3969/j.issn.1006-6233.2025.03.016

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Abstract Objective: To investigate the impact of transurethral holmium laser enucleation of the bladder tumor (HOLRBT) on postoperative urinary function recovery, quality of life, and prognosis in patients with non-muscle-invasive bladder cancer (NMIBC). Methods: A total of 105 patients who underwent bladder cancer surgery at our hospital from February 2020 to May 2023 were enrolled. Based on the surgical approach, patients were divided into a control group (n=50, transurethral resection of bladder tumor [TURBT]) and an observation group (n=55, HOLRBT). Perioperative indicators, clinical efficacy, postoperative bladder muscle layer acquisition rate, postoperative intravesical drug use, complications (bladder obturator reflex rate, bladder perforation rate), and quality of life were compared between the two groups. Patients were followed up for 1 year to record recurrence and survival rates. Results: Compared to the control group, the observation group had shorter surgical duration, bladder irrigation time, and catheter indwelling time, as well as reduced intraoperative blood loss (all P<0.05). The clinical efficacy rate in the observation group was 89.09%, significantly higher than the 72.00% in the control group (P<0.05). The observation group also showed lower postoperative bladder muscle layer acquisition rates and reduced intravesical drug use (both P<0.05). The bladder obturator reflex rate (9.09% vs 26.00%) and bladder perforation rate (3.64% vs 18.00%) were significantly lower in the observation group (all P<0.05). Quality of life scores (SF-36) were higher in the observation group (P<0.05). At 1-year follow-up, the recurrence rate in the observation group was 12.73% (7/55), significantly lower than the 30.00% (15/50) in the control group (χ²=4.718, P=0.030). Kaplan-Meier survival analysis indicated a higher 1-year cumulative survival rate in the observation group (87.30% vs 74.00%, Log-rank χ²=4.318, P=0.038). Conclusion: HOLRBT demonstrates significant prognostic value in NMIBC patients, effectively improving postoperative urinary function, enhancing quality of life, and reducing complications. It holds promising clinical application prospects.

Key words： Transurethral holmium laser enucleation of the bladder tumor Non-muscle-invasive bladder cancer Urinary function recovery Quality of life

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	Articles by authors
	WU Deming
	JIAO Changbao
	CHEN Jian
	et al

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WU Deming,JIAO Changbao,CHEN Jian, et al. Impact of Transurethral Holmium Laser Enucleation of Bladder Tumor on Postoperative Urinary Function Recovery Quality of Life and Prognosis in Non-Muscle-Invasive Bladder Cancer[J]. HeBei Med, 2025, 31(3): 439-444.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.03.016 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I3/439

[1] 戚宇,王杭,郭剑明,等.膀胱灌注卡介苗治疗中高危非肌层浸润性膀胱癌疗效预测模型的建立[J].复旦学报(医学版),2023,50(6):810-819.
[2] 王玮,李玮,杨俊哲,et al.连续时间随机行走扩散模型联合膀胱影像报告与数据系统诊断膀胱癌肌层浸润状态的研究[J].中华放射学杂志,2024,58(4):394-400.
[3] 唐多才,周术奎,张桂银,等.非肌层浸润性膀胱癌行初次经尿道膀胱肿瘤电切术的术后复发危险因素分析[J].中国癌症杂志,2023,33(5):478-483.
[4] Li C,Gao L,Zhang J,et al.The effect of holmium laser resection versus standard transurethral resection on non-muscle-invasive bladder cancer:a systematic review and meta-analysis[J].Lasers Med Sci,2020,35(5):1025-1034.
[5] Qiuhua Z,Yunxiang L I,Rong H U,et al.Effect of transurethral holmium laser enucleation versus transurethral resection of bladder tumor in treating non-muscle invasive bladder cancer[J].Clin Med Pract,2023,27(6):133-136.
[6] Huawei Y,Huilong T,Li L,et al.Comparison of efficacy between turning holmium laser en-bloc resection of bladder tumor and holmium laser en-bloc resection of bladder tumor in the treatment of non-muscle-invasive bladder cancer[J].Clin Urol,2020,35(11):878-881,886.
[7] Byrne-Kirk M,Mantzioris E,Scannell N,et al.Adherence to a Mediterranean-style diet and severity of menopausal symptoms in perimenopausal and menopausal women from Australia:a cross-sectional analysis[J].Eur Nutr,2024,63(7):2743-2751.
[8] Hashem A,Mosbah A,El-Tabey N A,et al.Holmium laser en-bloc resection versus conventional transurethral resection of bladder tumors for treatment of non-muscle-invasive bladder cancer:a randomized clinical trial[J].Eur Urol Focus,2021,7(5):1035-1043.
[9] Sheybaee Moghaddam F,Dwabe S,Mar N,et al.The role of maximal TURBT in muscle-invasive bladder cancer:balancing benefits in bladder preservation and beyond[J].Cancers,2024,16(19):3361.
[10] Razzaghi M R,Mazloomfard M M,Yavar M,et al.Holmium LASER in comparison with transurethral resection of the bladder tumor for non-muscle invasive bladder cancer:randomized clinical trial with 18-month follow-up[J].Urology Journal,2021,18(4):460-465.
[11] 陆佳伟,缪惠东,沈锋,等.钬激光治疗非肌层浸润性膀胱肿瘤的疗效及安全性[J].国际泌尿系统杂志,2022,42(3):452-456.
[12] 张秋华,李云祥,胡蓉,等.经尿道钬激光剜除术与经尿道膀胱肿瘤电切术对非肌层浸润性膀胱癌的疗效比较[J].实用临床医药杂志,2023,27(6):133-136.