新生儿黄疸患儿血清STAT3胆红素/白蛋白比值与病情严重程度的关系及临床意义

doi:10.3969/j.issn.1006-6233.2025.03.019

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Abstract Objective: To investigate the relationship and clinical significance of serum signal transducer and activator of transcription 3 (STAT3) and bilirubin/albumin ratio with the severity of neonatal jaundice. Methods: A total of 320 neonatal jaundice patients treated at our hospital from September 2023 to April 2024 were enrolled as the observation group, including 184 cases of physiological jaundice and 136 cases of pathological jaundice. Based on serum total bilirubin levels, the patients were further divided into mild (96 cases), moderate (164 cases), and severe (60 cases) groups. Additionally, 320 healthy newborns undergoing physical examinations during the same period were selected as the control group. Serum STAT3 levels were measured using enzyme-linked immunosorbent assay (ELISA), while total bilirubin and albumin levels were detected using a fully automated biochemical analyzer to calculate the bilirubin/albumin ratio. Spearman correlation analysis was used to assess the relationship between serum STAT3 levels, bilirubin/albumin ratio, and disease severity. Multivariate logistic regression analysis was performed to identify factors influencing disease severity. Receiver operating characteristic (ROC) curves were plotted to evaluate the predictive value of serum STAT3 levels and bilirubin/albumin ratio for therapeutic efficacy in neonatal jaundice. Results: Levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT) in the observation group were significantly higher than those in the control group (P<0.05). Serum STAT3 levels and bilirubin/albumin ratio were significantly higher in pathological jaundice compared to physiological jaundice (P<0.05). These levels were also significantly elevated in mild, moderate, and severe jaundice groups compared to the control group (P<0.05). Spearman correlation analysis revealed a positive correlation between serum STAT3 levels, bilirubin/albumin ratio, and disease severity (P<0.05). Neonatal jaundice patients with poor therapeutic outcomes exhibited significantly higher serum STAT3 levels and bilirubin/albumin ratio before treatment and at 1, 3, 5, and 7 days post-treatment compared to those with good outcomes (P<0.05). ROC curve analysis demonstrated that the combined prediction of serum STAT3 levels and bilirubin/albumin ratio had a significantly larger area under the curve (AUC) for predicting therapeutic efficacy compared to STAT3 alone (Z=4.700, P<0.001) or bilirubin/albumin ratio alone (Z=4.324, P<0.001). Conclusion: Serum STAT3 levels and bilirubin/albumin ratio are significantly elevated in neonatal jaundice patients and are closely associated with disease severity and therapeutic efficacy.

Key words： Neonatal jaundice STAT3 Bilirubin/albumin ratio Disease severity Therapeutic efficacy

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.03.019 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I3/457

[1] 范蓉,毛玉萍,王玲.双歧杆菌、维生素D联合蓝光照射治疗新生儿黄疸的临床疗效分析[J].医学理论与实践,2024,37(15):2619-2621.
[2] 吉英勇,陈阳,冯莹莹.茵栀黄口服联合间隙蓝光照射佐以双歧杆菌三联活菌对新生儿黄疸的效果研究[J].系统医学,2023,8(10):129-132.
[3] Rasiah S,Jegathesan T,Campbell DM,et al.Intravenous immunoglobulin G therapy for neonatal hyperbiliru-binemia[J].Pediatr Res,2023,94(6):2092-2097.
[4] 黎乃维,王飞,尧子钊,等.基于IL-6/STAT3信号通路研究冬凌草甲素对乳腺癌细胞的作用及机制[J].中草药,2022,53(13):4046-4052.
[5] 陈文香,随光辉,吴晓龙.血清STAT3和G6PD在新生儿高胆红素血症中的表达变化及临床意义[J].热带医学杂志,2023,23(6):797-802.
[6] Sahan H,Gulasi S,Mert MK,et al.The predictive significance of umbilical cord bilirubin and bilirubin/albumin ratio for neonatal jaundice in healthy term newborns[J].Turkish Journal of Medical Sciences,2023,53(2):511-517.
[7] 中华医学会儿科学分会新生儿学组,《中华儿科杂志》编辑委员会.新生儿高胆红素血症诊断和治疗专家共识[J].中华儿科杂志,2014,52(10):745-748.
[8] 邵肖梅,叶鸿瑁,丘小汕.实用新生儿学[M].第5版.北京:人民卫生出版社,2019.656-702.
[9] 王晓鹏,王娜,马俊苓,等.高胆红素血症新生儿血清25-羟维生素D₃粒细胞-巨噬细胞集落刺激因子及血清总胆红素/血清白蛋白比值对临床转归的预测价值[J].中国妇幼保健,2023,38(11):1993-1997.
[10] Ngashangva L,Bachu V,Goswami P.Development of new methods for determination of bilirubin[J].Journal of Pharmaceutical and Biomedical Analysis,2019,162(1):272-285.
[11] Christina H,Kristina S,Anabel S,et al.STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis[J].Gut,2020,69(7):1269-1282.
[12] Liang TQ,Kong YX,Tang LJ,et al.Network pharmacology-based analysis on the potential biological mechanisms of yinzhihuang oral liquid in treating neonatal hyperbilirubinemia[J].Evidence-Based Complementary and Alternative Medicine,2022,2022(1):1672670-1672671.
[13] 王海云,苌俊明,赵杰,等.新生儿病理性黄疸血清总胆红素、AST、ALT、ALB水平与蓝光治疗效果的关系[J].分子诊断与治疗杂志,2024,16(2):379-382.