外周血PD-1 Th1/Th2及Th17/Treg与特应性皮炎的相关性研究

doi:10.3969/j.issn.1006-6233.2025.03.020

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Abstract Objective: To discuss the correlation between peripheral blood PD-1, Th1/Th2, Th17/Treg and atopic dermatitis (AD). Methods: A total of 90 AD patients admitted to our hospital from Jun 2022 to Feb 2024 were selected as the study subjects, and divided into the moderate group (SCORAD severity index score 25-50, 51 cases) and the severe group (SCORAD score>50, 39 cases) based on the severity of the AD condition. Additionally, 50 non-AD patients admitted to our hospital during the same period were selected as the control group. Recorded and analyzed the eczema area and severity index (EASI) score, SCORAD, patient self-evaluation (POEM) and itching score of AD patients, as well as peripheral blood PD-1, Th1/Th2, Th17/Treg values. Spearman rank correlation analysis was used to explore the correlation between the two variables, and ROC curve was used to evaluate the effectiveness of PD-1, Th1/Th2 and Th17/Treg in predicting the severity of AD. Results: The scores of EASI (13.94±3.35), SCORAD (57.02±6.78), POEM (24.11±3.12) and pruritus severity score (8.98±1.03) of the severe group were higher than the moderate group (t-values were 6.444,7.638,9.133,8.873 respectively, P<0.05). The PD-1 (285.63±34.78) pg/ml, Th17 (9.65±1.97)%, Treg (2.71±1.04)% and Th17/Treg (3.62±0.69) of the severe group were higher than the moderate group, while Th1 (7.89±0.79)%, Th2 (2.34±0.45)%, and Th1/Th2 (3.21±0.57) were lower than the moderate group (P<0.05). The results of multiple logistic regression analysis showed that EASI score, SCORAD score, POEM score, itch severity score, PD-1, Th1/Th2, and Th17/Treg were independent risk factors for the severity of AD patients (all P<0.05). The PD-1 and Th17/Treg were positively correlated with EASI, SCORAD, POEM and itching severity scores (P<0.05); while the Th1/Th2 was negatively correlated with EASI, SCORAD, POEM and itching severity scores (P<0.05). The AUC value of PD-1+Th1/Th2+Th17/Treg combined prediction for the severity of AD was 0.979, with the sensitivity 94.87% and the specificity of 96.08%, which indicating that PD-1+Th1/Th2+Th17/Treg combined prediction had a higher efficiency in predicting the severity of AD. Conclusion: Peripheral blood PD-1, Th17/Treg levels were significantly increased and Th17/Treg levels were significantly decreased in AD patients, while peripheral blood PD-1, Th17/Treg levels were significantly increased and decreased in severe AD patients. PD-1, Th1/Th2 and Th17/Treg levels were closely related to the severity of AD. The combined detection of PD-1+Th1/Th2+Th17/Treg can improve the evaluation of AD severity.

Key words： Atopic dermatitis Severity PD-1 Th1/Th2 Th17/Treg Correlation

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.03.020 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I3/464

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