地塞米松小剂量辅助TACE在原发性肝癌治疗中的抗炎与肝功能保护作用研究

doi:10.3969/j.issn.1006-6233.2025.04.015

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Abstract Objective: To explore the anti-inflammatory and liver function protective effects of low-dose dexamethasone-assisted hepatic artery chemoembolization (TACE) in the treatment of primary liver cancer (PLC). Methods: A total of 256 patients with PLC treated in our hospital from January 2020 to September 2024 were randomly divided into a control group (n=128, TACE treatment) and a study group (n=128, low-dose dexamethasone assisted TACE treatment) using a block randomization method. The inflammatory factors, liver function, tumor markers, and efficacy of the two groups were compared. Results: Compared with preoperative levels, the postoperative levels of tumor necrosis factor (TNF) - α, C-reactive protein (CRP), and interleukin-6 (IL-6) increased in both groups 7days after surgery (P<0.05), and the levels of IL-2 decreased in both groups 7days after surgery (P<0.05). Compared with the control group, the study group had lower differences in TNF - α, CRP, IL-2, and IL-6 before and after surgery (P<0.05). Compared with preoperative levels, the postoperative levels of direct bilirubin (DBIL), total bilirubin (TBIL), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) increased in both groups 7days after surgery (P<0.05). Compared with the control group, the study group had lower differences in DBIL, TBIL, AST, and ALT before and after surgery (P<0.05). Compared with preoperative levels, the postoperative levels of alpha fetoprotein (AFP) and cytokeratin 19 (CK19) in both groups decreased at 7 days after surgery (P<0.05). Compared with the control group, the study group had higher differences in AFP and CK19 before and after surgery (P<0.05). The objective response rate (DRR) and disease control rate (DCR) of the research group were 75.00% and 88.28%, respectively, which were higher than the control group's 62.50% and 70.31% (P<0.05). Conclusion: Dexamethasone low-dose adjuvant TACE has significant anti-inflammatory and liver function protective effects in PLC treatment, and can reduce tumor marker levels, improving treatment efficacy.

Key words： Primary liver cancer Hepatic artery chemoembolization Dexamethasone Liver function

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.04.015 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I4/619

[1] 朱玟霜,邱华,李旺,等.白花香莲解毒颗粒联合经肝动脉化疗栓塞术治疗HBV相关性原发性肝癌的疗效及对免疫功能的影响[J].中西医结合肝病杂志,2023,33(3):213-216.
[2] 王晓维,蒋逢辰,周水平,等.肝动脉栓塞化疗术联合微波消融治疗早期原发性肝癌的疗效观察[J].介入放射学杂志,2024,33(5):488-494.
[3] Haaft B H E A T,Franssen S,Dorst R W J J V,et al.ASO visual abstract:robotic versus open hepatic arterial infusion pump placement for unresectable intrahepatic cholangiocarcinoma[J].Annals of Surgical Oncology,2024,31(6):4059-4060.
[4] Yunxiuxiu X,Peng L,Chen Y,et al.Apatinib and camrelizumab plus Intravenous FOLFOX or hepatic arterial infusion chemotherapy with FOLFOX for advanced HCC:A multicenter,prospective,randomized phase III trial.[J].Journal of Clinical Oncology,2024,42(16):4193-4193.
[5] 国家卫生健康委员会医政医管局.原发性肝癌诊疗规范(2019年版)[J].中华肝脏病杂志,2020,28(2):112-128.
[6] Guiu B,Garin E,Allimant C,et al.TARE in hepatocellular carcinoma:from the right to the left of BCLC[J].Cardiovasc Intervent Radiol,2022,45(11):1599-1607.
[7] Thuring J,Rippel O,Haarburger C,et al.Multiphase CTbased prediction of child-pugh classification:a machine learningapproach[J].Eur Radiol Exp,2020,4(1):20
[8] Hepatic artery infusion chemotherapy (HAIC) combined with sintilimab and bevacizumab biosimilar (IBI305) for initial unresectable hepatocellular carcinoma (HCC):a prospective,single-arm phase II trial.[J].Journal of Clinical Oncology,2022,40(16):4073-4073.
[9] Yan J,Sun Y,Fan D M W.Apatinib plus drug-eluting bead transarterial chemoembolization as bridging therapy to surgical resection displays an acceptable efficacy and safety profile in hepatocellular carcinoma patients[J].Indian journal of cancer,2023,60(4):562-569
[10] Lissing M,Wester A,Wahlin S S.Porphyrin precursors and risk of primary liver cancer in acute intermittent porphyria:a case–control study of 188 patients[J].Journal of inherited metabolic disease,2023,46(6):1186-1194.
[11] 王兴林,郭志伟,黄建儒,等.MRI增强扫描对原发性肝癌患者肝动脉化疗栓塞术后MVI预后的预测价值[J].广西医科大学学报,2023,40(12):2043-2050.

[1]	. [J]. HeBei Med, 2024, 30(2): 345-348.