Caveolin-3 TLR4在老年心力衰竭并发心律失常患者血清中的表达及预后价值

doi:10.3969/j.issn.1006-6233.2025.04.014

Abstract
Figure/Table
References
Related Citation (15)

Download: PDF (1355 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract Objective: To investigate the expression and prognostic value of caveolin-3 and Toll-like receptor 4 (TLR4) in the serum of elderly patients with heart failure (HF) complicated by arrhythmia. Methods: A total of 96 patients with heart failure complicated by arrhythmia admitted to our hospital from June 2022 to June 2023 were included as the study group, and 98 patients without heart failure complicated by arrhythmia were included as the control group. Adverse cardiovascular events that occurred during the 12-month follow-up period were recorded, and the patients were assigned to a poor prognosis group (n=33) and a good prognosis group (n=63) based on the results. Enzyme linked immunosorbent assay was applied to detect the expression levels of Caveolin-3 and TLR4 in serum. Multivariate logistic regression was applied to analyze the factors affecting the prognosis of patients with heart failure complicated by arrhythmia. The receiver operating characteristic (ROC) curve was plotted to analyze the predictive value of Caveolin-3 and TLR4 levels for poor prognosis in patients with heart failure complicated by arrhythmia. Results: Compared with the control group, the serum TLR4 level was higher and Caveolin-3 level was lower in the study group (t=8.393, 10.228, all P<0.05). The difference in cardiac function grading between the poor prognosis group and the good prognosis group was statistically obvious (χ²=35.024, P<0.05). The serum TLR4 level in the poor prognosis group was higher than that in the good prognosis group, while the Caveolin-3 and LVEF levels were lower than those in the good prognosis group (t=6.510, 7.280, 3.816, all P<0.05). Multivariate logistic regression analysis showed that cardiac function grading and TLR4 level were risk factors for poor prognosis, while LVEF and Caveolin-3 levels were protective factors for poor prognosis (P<0.05). ROC curve showed that the AUC of predicting poor prognosis in patients with heart failure complicated by arrhythmia by serum Caveolin-3 and TLR4 levels was 0.775 and 0.854, respectively. The AUC predicted by the combination of the two was 0.898, higher than that of single indicator detection (Z=2.964, P=0.003, Z=2.111, P=0.035). Conclusion: The serum level of Caveolin-3 is decreased and TLR4 is increased in patients with heart failure complicated by arrhythmia. The combined detection of the two can be used as serum markers to evaluate the poor prognosis of patients with heart failure complicated by arrhythmia.

Key words： Heart failure Arrhythmia Caveolin-3 Toll-like receptor 4 Prognosis

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	KE Chunfeng
	CAO Yi
	TANG Yan
	et al

Cite this article:

KE Chunfeng,CAO Yi,TANG Yan, et al. Expression and Prognostic Value of Caveolin-3 and TLR4 in Serum of Elderly Patients with Heart Failure Complicated by Arrhythmia[J]. HeBei Med, 2025, 31(4): 614-619.

URL:

http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.04.014 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I4/614

[1] Zheng YY,Wu TT,Hou XG,et al.Serum a-1 antitrypsin as a novel biomarker in chronic heart failure[J].ESC Heart Fail,2023,10(5):2865-2874.
[2] Radhoe SP,Brugts JJ.CardioMEMS^TM:a tool for remote hemodynamic monitoring of chronic heart failure patients[J].Future Cardiol,2022,18(3):173-183.
[3] Zhang Y,Xiong X,Wang J,et al.Prognostic value of serum IGF-1,Gal-3,and PTX-3 levels in elderly patients with chronic heart failure[J].Am Transl Res,2024,16(4):1393-1400.
[4] Zhang Z,Fang Q,Du T,et al.Cardiac-specific Caveolin-3 overexpression prevents post-myocardial infarction ventricular arrhythmias by inhibiting ryanodine receptor-2 hyperphosphorylation[J].Cardiology,2020,145(3):136-147.
[5] Vaez H,Soraya H,Garjani A,et al.Toll-like receptor 4 (TLR4) and AMPK relevance in cardiovascular disease[J].Adv Pharm Bull,2023,13(1):36-47.
[6] 葛均波,徐永健,王辰.内科学[M].第9版.北京:人民卫生出版社,2018.124-138.
[7] Bredy C,Ministeri M,Kempny A,et al.New York Heart association(NYHA)classification in adults with congenital heart disease:relation to objective measures of exercise and outcome[J].Eur Heart Qual Care Clin Outcomes,2018,4(1):51-58.
[8] Amaechi UM,Aiwuyo HO,Ewelukwa C,et al.Assessing iron status in chronic heart failure patients by using serum ferritin and transferrin saturation levels:a cross-sectional descriptive study[J].Cureus,2023,15(5):e39425.
[9] 杨静静.慢性心力衰竭患者血清NT-proBNP、Hcy水平变化及其对心律失常的预测价值[J].黑龙江医药科学,2024,47(1):168-170.
[10] Frantz S,Hundertmark MJ,Schulz-Menger J,et al.Left ventricular remodelling post-myocardial infarction:pathophysiology,imaging,and novel therapies[J].Eur Heart,2022,43(27):2549-2561.
[11] Youssef ME,Abdelrazek HM,Moustafa YM,et al.Inhibition of Toll-like Receptor-4 expression for amelioration of myocardial injury in diabetes:A meta-analysis[J].Clinics (Sao Paulo),2022,77(1):100137-100145.
[12] Yuan J,Yin X,Jiang H.Inhibition of toll-like receptor-4 expression for amelioration of myocardial injury in diabetes:a meta-analysis[J].Clinics (Sao Paulo),2022,77(1):100137-100145.
[13] 曾润生,梁玉鹃,蔡承哲,等.外周血TLR4、CysC联合检测对冠心病患者PCI术后1年内ISR发生的预测价值[J].吉林医学,2023,44(11):3063-3067.
[14] He M,Qiu J,Wang Y,et al.Caveolin-3 and Arrhythmias:Insights into the Molecular Mechanisms[J].J Clin Med,2022,11(6):1595-1608.
[15] Benzoni P,Gazzerro E,Fiorillo C,et al.Caveolin-3 and caveolin-1 interaction decreases channel dysfunction due to caveolin-3 mutations[J].Int Mol Sci,2024,25(2):980-998.
[16] Guo P,Hu S,Liu X,et al.Caveolin-3alleviates diabetic cardiomyopathy via inhibiting NDUFA10-mediated mitochondrial dysfunction[J].Transl Med,2024,22(1):390-409.
[17] 刘宇彤,郭俊凡,张岳甫,等.睡眠剥夺对缺血再灌注后心肌Caveolin-3表达与细胞凋亡的影响[J].武汉大学学报(医学版),2024,45(1):14-18.