肠道菌群代谢产物外周血中性粒细胞NETs与急性胰腺炎肺损伤及预后的关系分析

doi:10.3969/j.issn.1006-6233.2025.04.018

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Abstract Objective: To analyze the relationship between intestinal flora metabolites, neutrophil extracellular traps (NETs), and acute pancreatitis lung injury (AP-ALI) and prognosis. Methods: A total of 150 patients with AP-ALI admitted from May 2022 to May 2024 were established as the observation group and 60 patients with simple acute pancreatitis (AP) were established as the control group during the same period. Feces and peripheral blood samples were collected to detect intestinal flora metabolites (acetic acid, propionic acid, butyric acid) and NETs levels, Logistic regression analysis was used to determine whether intestinal flora metabolites and NETs were related to AP-ALI. According to the prognosis within 90 days, 150 AP-ALI patients were divided into a poor prognosis group and a good prognosis group. Clinical data were collected, Logistic regression analysis was used to screen risk factors affecting the poor prognosis of AP-ALI patients, ROC curve was plotted to evaluate the efficacy of intestinal flora metabolites and NETs in predicting poor prognosis of AP-ALI patients. Results: Compared with the control group, acetic acid, propionic acid, and butyric acid levels in the observation group were lower (P<0.05) and NETs levels were higher (P<0.05). Acetic acid (OR=1.222), propionic acid (OR=1.342), butyric acid (OR=1.229), and NETs (OR=1.282) were closely related to AP-ALI (P<0.05). Compared with the good prognosis group, BMI, diabetes proportion, and procalcitonin, D-lactic acid, and NETs levels in the poor prognosis group were higher, and oxygen saturation, acetic acid, propionic acid, butyric acid levels were lower, with statistically significant difference (P<0.05). BMI (OR=1.252), diabetes mellitus (OR=1.242), oxygen saturation (OR=1.229), procalcitonin (OR=1.305), D-lactic acid (OR=1.304), acetic acid (OR=1.410), propionic acid (OR=1.424), butyric acid (OR=1.404) and NETs (OR=1.442) were independent risk factors for poor prognosis in AP-ALI patients (P<0.05). ROC curve showed that the sensitivity and AUC of intestinal flora metabolites (acetic acid, propionic acid, butyric acid) and NETs in predicting poor prognosis of AP-ALI patients were 90.50% and 0.907 respectively, and the predictive value was good. Conclusion: The abnormal changes of intestinal flora metabolites (acetic acid, propionic acid, butyric acid) and NETs levels in AP-ALI patients are closely related to the occurrence and prognosis of AP-ALI, which provides a reference basis for early recognition of AP-ALI and improvement of prognosis of patients.

Key words： Acute pancreatitis Acute lung injury Intestinal flora metabolites Neutrophils extracellular trap

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	ZHANG Zhichao
	ZHU Xuehe
	WANG Qi
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Cite this article:

ZHANG Zhichao,ZHU Xuehe,WANG Qi, et al. Analysis of the Relationship Between Intestinal Flora Metabolites Peripheral Neutrophils NETs and Lung Injury and Prognosis in Acute Pancreatitis[J]. HeBei Med, 2025, 31(4): 636-648.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.04.018 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I4/636

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