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| Study on Correlation between Neutrophil Coagulation Parameters and Deep Venous Thrombosis Occurrence after Total Knee Arthroplasty |
| DILIARE·Erken, WUHUZI ·Wulamu, XU Yi, LIU Jingya, et al |
| The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Urumqi 830000, China |
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Abstract Objective: To analyze the correlation between neutrophil count (NC), coagulation parameters and deep venous thrombosis (DVT) after total knee arthroplasty (TKA). Methods: Totally 364 patients who received TKA in the hospital from September 2022 to September 2023 were divided into thrombosis group (n=42) and non-thrombosis group (n=322) according to whether DVT occurred after surgery. Peripheral blood NC, D-D, Fib, APTT, PT and TT of all study subjects were measured at 3 days after surgery. Logistic regression analysis was adopted to explore the relationship between NC and coagulation parameters with the occurrence of DVT after TKA. The predictive value of NC and coagulation parameters on the occurrence of postoperative DVT was investigated by receiver operating characteristic curve (ROC). Results: At 3 days after surgery, the levels of NC, D-D, and Fib in the thrombosis group were higher than those in the non-thrombosis group (P<0.05), but there were no obvious differences in APTT, PT and TT between groups (P>0.05). Logistic regression analysis suggested that the levels of NC, D-D, and Fib were independent risk factors of DVT occurrence after TKA (P<0.05). ROC curve showed that 3 days after surgery, the area under the curve (AUC) of NC, D-D, and Fib independently predicted the occurrence of deep vein thrombosis after total knee replacement was 0.636, 0.724 and 0.664, respectively, and the sensitivity was 45.24%, 47.62% and 66.67%, respectively. The specificity was 81.68%, 88.82%, 64.60%, respectively. The AUC of the combined prediction was 0.905, the sensitivity was 85.71%, and the specificity was 80.43%. The combined prediction efficiency was better than that of each index alone (P<0.05). Conclusion: The occurrence of DVT after TKA is closely related to the postoperative NC and coagulation parameters. The determination of NC and coagulation parameters after surgery can be used to understand the risk of lower extremity DVT, to guide clinical early prevention and treatment measures.
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2025, Vol. 31 
