血清IGF-1 VEGF TSH指数表达水平与脑小血管病认知障碍进展至痴呆的相关性分析

doi:10.3969/j.issn.1006-6233.2025.05.015

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Abstract Objective: To explore the correlation between the expression levels of serum insulin-like growth factor-1 (IGF-1), vascular endothelial growth factor (VEGF), and thyroid-stimulating hormone (TSH) index, and the progression of cognitive impairment to dementia in cerebral small vessel disease (CSVD), to provide a reference for clinical prevention and treatment. Methods: A total of 210 CSVD patients with cognitive impairment admitted to the hospital from May 2020 to May 2023 were selected and treated with symptomatic treatment. They were followed up for 1 year and assigned to a dementia group and a non-dementia group based on whether their cognitive impairment progressed to dementia. Clinical data were collected from all patients, and 5 mL of fasting venous blood was collected early in the morning of the day following the admission of all patients to detect the levels of serum IGF-1, VEGF, and TSH indices. The clinical data, serum levels of IGF-1, VEGF, and TSH indices were compared between the two groups, the correlation between serum levels of IGF-1, VEGF, and TSH indices and the severity of cognitive impairment and dementia was analyzed, the predictive value of each serum marker for the progression of CSVD cognitive impairment to dementia was evaluated. Results: Compared with the non-dementia group, the dementia group had higher proportions of alcohol consumption, family history of dementia, and total CSVD imaging burden scores at baseline, as well as lower MoCA scores and proportions of regular anti-cognitive impairment treatment at baseline (all P<0.05). Compared with the non-dementia group (97.28±14.15) ng/mL, (248.77±40.61) ng/L, and (133.27±13.58) mIU/L, the dementia group had lower serum IGF-1 and VEGF levels [(83.65±10.40) ng/mL and (210.49±35.23) ng/L, respectively], and a higher TSH index level (151.45±18.72) mIU/L (t=5.471, 5.762, 6.791, all P<0.05); serum IGF-1 and VEGF were negatively correlated with the total burden score of CSVD imaging at baseline, and positively correlated with MoCA score; the TSH index was positively correlated with the total burden score of CSVD imaging at baseline, and negatively correlated with MoCA score (P<0.05). Before and after correcting other factors, serum IGF-1, VEGF, and TSH indices were still independently associated with the progression of CSVD cognitive impairment to dementia (P<0.05). The AUCs of serum IGF-1, VEGF, and TSH index for predicting the progression of CSVD cognitive impairment to dementia were 0.776 (95%CI: 0.713~0.831), 0.812 (95%CI: 0.752~0.863), and 0.821 (95%CI: 0.762~0.871), respectively; the AUC of the three combined predictors for the progression of CSVD cognitive impairment to dementia was 0.932 (95%CI: 0.888~0.962), with a sensitivity of 88.89% and a specificity of 84.71%; the predictive value was significantly higher than that of each predictor (P<0.05). Conclusion: The serum levels of IGF-1, VEGF, and TSH indices are significantly correlated with the condition of patients with CSVD cognitive impairment, which are independent factors contributing to the progression to dementia, and their combined predictive value is reliable.

Key words： Cerebral small vessel disease Cognitive impairment Dementia Insulin-like growth factor-1 Vascular endothelial growth factor Thyroid stimulating hormone index

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	BAI Yanchang
	CHEN Shanpeng
	SUN Qianyu
	et al

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BAI Yanchang,CHEN Shanpeng,SUN Qianyu, et al. Correlation Analysis of Serum IGF-1 VEGF and TSH Index Expression Levels with the Progression of Cognitive Impairment to Dementia in Patients with Cerebral Small Vessel Disease[J]. HeBei Med, 2025, 31(5): 788-794.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.05.015 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I5/788

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