ABCD2评分联合外周血Hcy GSH-Px水平预测短暂性脑缺血发作患者预后的价值分析

doi:10.3969/j.issn.1006-6233.2025.05.017

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Abstract Objective: To explore the value of ABCD2 score combined with peripheral blood homocysteine (Hcy) and glutathione peroxidase (GSH-Px) levels on predicting the prognosis of patients with transient ischemic attack (TIA). Methods: A total of 126 patients with TIA from December 2022 to August 2024 were retrospectively analyzed and included in TIA group. According to whether acute cerebral infarction occurred within 7 days, the patients in TIA group were divided into ACI group (n=29) and non-ACI group (n=97). The baseline data, ABCD2 score and peripheral blood indexes (Hcy, GSH-Px) were compared between ACI group and non-ACI group. ABCD2 score and peripheral blood indexes (Hcy, GSH-Px) were compared between ACI group and non-ACI group. Pearson correlation analysis was used to explore the correlation between each index and clinical data. Binary logistic equation was adopted to analyze the related influencing factors of acute cerebral infarction in patients. ROC curve was drawn to analyze the diagnostic value of ABCD2 score combined with peripheral blood Hcy and GSH-Px levels on the prognosis in TIA group. Results: Hypertension, diabetes, attack duration, attack frequency, TC and TG in ACI group were significantly higher than those in non ACI group (P<0.05). The ABCD2 scores and peripheral blood Hcy levels in the ACI group were significantly higher than those in the non ACI group (P<0.05), while GSH Px was significantly lower than those in the non ACI group (P<0.05). ABCD2 score and Hcy were significantly positively correlated with attack duration, attack frequency, TC and TG (P<0.05), and GSH-Px was significantly negatively correlated with each index (P<0.05). The ABCD2 score and peripheral blood Hcy level in ACI group were significantly higher (P<0.05) while the GSH-Px was significantly lower compared to non-ACI group (P<0.05). ABCD2 score and levels of Hcy and GSH-Px in peripheral blood were correlated with acute cerebral infarction (P<0.05). The AUCs of ABCD2 score, peripheral blood Hcy and GSH-Px in predicting the poor prognosis of patients were 0.638, 0.677 and 0.701 respectively. The AUC of the combination of the three indexes for poor prognosis of patients was 0.770, and the combined diagnostic value was higher. Conclusion: ABCD2 score and levels of peripheral blood Hcy and GSH-Px are correlated with transient ischemic attack and poor prognosis, which are expected to be used as reference indexes.

Key words： Transient ischemic attack Acute cerebral infarction ABCD2 score Homocysteine Glutathione peroxidase

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	WANG Yixu
	ZHANG Jing

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WANG Yixu,ZHANG Jing. Value of ABCD2 Score Combined with Peripheral Blood Hcy and GSH-Px Levels on Predicting the Prognosis of Patients with Transient Ischemic Attack[J]. HeBei Med, 2025, 31(5): 800-806.

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http://www.hbyxzzs.cn/EN/10.3969/j.issn.1006-6233.2025.05.017 OR http://www.hbyxzzs.cn/EN/Y2025/V31/I5/800

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